AI Article Synopsis
- (18)F-FDG PET shows potential for identifying vulnerable plaques in atherosclerosis but its effectiveness at different lesion stages is still uncertain.
- The study examined how foam cell formation in mouse macrophages affects (18)F-FDG uptake.
- Findings indicated that (18)F-FDG accumulation increases with foam cell formation, but decreases after complete differentiation, suggesting it is more effective at detecting early stages of foam cell formation in atherosclerosis.*
Article Abstract
Unlabelled: (18)F-FDG PET is a promising tool for detecting vulnerable plaques, depending on the extent of macrophage infiltration; however, it is still not clear which stage of the lesion can be detected by (18)F-FDG PET.
Methods: In this study, we investigated the effect of foam cell formation on (18)F-FDG uptake using cultured mouse peritoneal macrophages.
Results: (18)F-FDG accumulation was increased by foam cell formation, but the uptake was decreased to the control level after complete differentiation to foam cells. Changes in hexokinase activity tended to accompany changes in (18)F-FDG uptake. In contrast, changes in glucose-6-phosphatase activity and glucose transporter 1 expression did not parallel (18)F-FDG uptake.
Conclusion: Our results suggest that (18)F-FDG PET detects the early stage of foam cell formation in atherosclerosis.
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| http://dx.doi.org/10.2967/jnumed.111.092866 | DOI Listing |
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