Background: Laser tissue welding (LTW) is a novel method of surgical wound closure by the use of laser radiation to induce fusion of the biological tissues. Molecular dynamics associated with LTW is a result of thermal and non-thermal mechanisms.
Objectives: This research focuses exclusively on better heat management to reduce thermal damage of tissues in LTW using a near infrared laser radiation.
Methods: An infrared continuous-wave (CW) laser radiation at 1,450 nm wavelength corresponding to the absorption band from combination vibrational modes of water is used to weld together ex vivo porcine aorta.
Results: In these studies we measured the optimal laser power and scan speed, for better tensile strength of the weld and lesser tissue dehydration. Significant amount of water loss from the welded tissue results in cellular death and tissue buckling. Various thermally conductive optical cover windows were used as heat sinks to reduce thermal effects during LTW for the dissipation of the heat. The optimal use of the method prevents tissue buckling and minimizes the water loss. Diamond, sapphire, BK7, fused silica, and IR quartz transparent optical cover windows were tested.
Conclusions: The data from this study suggests that IR-quartz as the material with optimal thermal conductivity is ideal for laser welding of the porcine aorta.
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http://dx.doi.org/10.1002/lsm.21143 | DOI Listing |
J Am Chem Soc
January 2025
School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 21 Nanyang Link, 637371, Singapore.
Photodynamic therapy (PDT) holds promise as a cancer treatment modality due to its potential for enhanced therapy precision and safety. To enhance deep tissue penetration and minimize tissue adsorption and phototoxicity, developing photosensitizers activated by second near-infrared window (NIR-II) light shows significant potential. However, the efficacy of PDT is often impeded by tumor microenvironment hypoxia, primarily caused by irregular tumor vasculature.
View Article and Find Full Text PDFAdv Healthc Mater
January 2025
Department of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Ji'nan, Shandong, 250014, China.
The porous structure is crucial in bone tissue engineering for promoting osseointegration. Among various structures, triply periodic minimal surfaces (TPMS) -Gyroid has been extensively studied due to its superior mechanical and biological properties. However, previous studies have given limited attention to the impact of unit cell size on the biological performance of scaffolds.
View Article and Find Full Text PDFGels
January 2025
School of Chemical Engineering, Yeungnam University, Gyeongsan 38541, Republic of Korea.
Hydrogels are widely utilized in industrial and scientific applications owing to their ability to immobilize active molecules, cells, and nanoparticles. This capability has led to their growing use in various biomedical fields, including cell culture and transplantation, drug delivery, and tissue engineering. Among the available synthesis techniques, ionizing-radiation-induced fabrication stands out as an environmentally friendly method for hydrogel preparation.
View Article and Find Full Text PDFDent J (Basel)
December 2024
Faculty of Dental Medicine, "Victor Babes" University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania.
Oral cancer ranks among the top ten cancers globally, with a five-year survival rate below 50%. This study aimed to evaluate the effectiveness of autofluorescence-guided surgery compared to standard surgical methods in identifying tumor-free margins and ensuring complete excision. A prospective cohort of 80 patients was randomized into two groups: the control group underwent excision with a 10 mm margin based on clinical judgment, while the experimental group used autofluorescence guidance with a 5 mm margin beyond fluorescence visualization loss.
View Article and Find Full Text PDFBackground: During last ten years, we have developed a digital library with educational materials in Physical medicine and rehabilitation.
Objectives: The objective of current article is the preparation of an electronic library with educational materials in the area of physical medicine, physical therapy and rehabilitation, and the comparative evaluation of the impact of this repository on the quality of education of students and trainees in the field.
Methodology: The electronic library includes e-books on different topics, elements of the specialty "Physical and rehabilitation medicine (PRM)" or Physiatry - with theoretical data, practical issues and case reports with videos of real patients.
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