AI Article Synopsis
- A high-throughput roll-to-roll (R2R) process is introduced for making foil-based PMMA chips with excellent optical quality, intended for identifying the mecA antibiotic resistance gene in Staphylococcus epidermidis.
- R2R hot embossing is highlighted as an innovative method for creating polymer microfluidic devices, utilizing a heated embossing cylinder to shape the polymer foil.
- Despite the potential for mass fabrication of these microfluidic chips for biological uses being recognized in the past, this study marks the first published research in this area.
Article Abstract
We present a high-throughput roll-to-roll (R2R) manufacturing process for foil-based polymethyl methacrylate (PMMA) chips of excellent optical quality. These disposable, R2R hot embossed microfluidic chips are used for the identification of the antibiotic resistance gene mecA in Staphylococcus epidermidis. R2R hot embossing is an emerging manufacturing technology for polymer microfluidic devices. It is based on continuous feeding of a thermoplastic foil through a pressurized area between a heated embossing cylinder and a blank counter cylinder. Although mass fabrication of foil-based microfluidic chips and their use for biological applications were foreseen already some years ago, no such studies have been published previously.
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| http://dx.doi.org/10.1039/c1lc20782b | DOI Listing |
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