AI Article Synopsis
- The study explored how different levels of NAVA and PSV affect breathing patterns in patients with acute respiratory failure.
- Three patients could not tolerate the highest NAVA levels, which indicated issues with comfort at elevated settings.
- The findings suggest that lower NAVA levels (below 2-2.5 cmH(2)O/μV) effectively reduce diaphragm activity while maintaining respiratory variability and minimizing the risk of high tidal volumes.
Article Abstract
Purpose: To investigate the effect of a wide range of assistance levels during neurally adjusted ventilatory assist (NAVA) and pressure support ventilation (PSV) on respiratory pattern, breathing variability, and incidence of tidal volumes (V (T)) above 8 and 10 ml/kg in acute respiratory failure patients.
Methods: Eight increasing NAVA levels (0.5, 1, 1.5, 2, 2.5, 3, 4, and 5 cmH(2)O/μV) and four increasing pressure support (PSV) levels (4, 8, 12, and 16 cmH(2)O) were applied to obtain 10 min of stable recordings in 15 patients.
Results: One out of 15 patients did not sustain the NAVA levels of 3, 4, and 5 cmH(2)O/μV and was excluded. The 5 cmH(2)O/μV NAVA level was not tolerated by three patients and it was excluded. Increasing NAVA levels were associated with decreased diaphragm electrical activity (EAdi), and, at variance with PSV, with small changes in V (T), no changes in respiratory rate (RR), and increases in V (T) and EAdi variability. At high NAVA levels, an increase in V (T) variability was associated with increased incidence of V (T) above 8 and 10 ml/kg and an uncomfortable respiratory pattern in some patients.
Conclusions: Increasing NAVA levels were associated with no effect on RR, small increase in V (T), and increase in V (T) and EAdi variability. Effective decrease in EAdi occurred at NAVA levels below 2-2.5 cmH(2)O/μV, while preserving respiratory variability and low risks of V (T) above 8 or 10 ml/kg.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00134-011-2433-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Mineral composition in mussel and clam from Faro Lake of Messina: risk assessment for human health.
Front Toxicol
December 2024
Department of Veterinary Sciences, University of Messina, Messina, Italy.
Bivalve are exposed to a wide range of contaminants, some of which may be toxic to human health. The aim of this study was to detect essential and non-essential elements such as Na, Ca, Mg, Cr, Mn, Fe, Ni, Cu, Zn, As, Cd, Pb, Hg, Be and Co in water, sediments, and and from Faro Lake. It is a lake of marine origin located on the northern coast of Messina (Sicily), where shellfish farming has been practiced for many years.
View Article and Find Full Text PDFSpatiotemporal heterogeneity of Rhipicephalus microplus resistance to chemical acaricides at intra-farm level: A case study using ivermectin.
Med Vet Entomol
December 2024
Instituto de Investigación de la Cadena Láctea (IdICaL) (INTA-CONICET), Instituto Nacional de Tecnología Agropecuaria, INTA E.E.A. Rafaela, Rafaela, Argentina.
The aim of this work was to analyse the spatiotemporal heterogeneity of Rhipicephalus microplus (Canestrini, 1888) (Acari: Ixodidae) resistance to chemical acaricides at intra-farm level under different environmental (favourable and unfavourable areas for tick development) and management (different schemes of acaricides applications) conditions using ivermectin as a model. The in vitro larval immersion test (LIT) was used to determine quantitatively the levels of resistance to ivermectin in the different populations and subpopulations of R. microplus analysed.
View Article and Find Full Text PDFAssociation between the early or late onset of gestational diabetes mellitus with neonatal adverse outcomes: a retrospective cohort study.
Clin Diabetes Endocrinol
December 2024
Postgraduate Program on Tocogynecology, Botucatu Medical School, São Paulo State University (Unesp), Botucatu, Brazil.
Background: The literature has been evolving to standardize gestational diabetes mellitus (GDM) diagnosis and terminology. The significance of timing in diagnosing hyperglycemia during pregnancy is underlined by evidence that women diagnosed at 24 weeks of gestation or earlier are at a higher risk of developing postpartum prediabetes, but its association with adverse outcomes for the newborn is controversial. We aimed to investigate the association between early-onset GDM and adverse outcomes in newborns and neonates, comparing it with the late-onset GDM model.
View Article and Find Full Text PDFTraining Status Influences Regulation of Muscle and PBMC TLR4 Expression and Systemic Cytokine Responses to Vigorous Endurance Exercise.
Med Sci Sports Exerc
November 2024
Department of Applied Physiology & Kinesiology, University of Florida, Gainesville, FL.
Introduction: A bout of vigorous endurance exercise transiently activates Toll-like receptor 4 (TLR4) and reduces TLR4 protein expressed on peripheral blood mononuclear cells (PBMCs). Endurance training, on the other hand, reduces TLR4-mediated signaling and minimizes the physiological stress imposed by exercise. Less is known about what occurs in skeletal muscle regarding TLR4 regulation and signaling.
View Article and Find Full Text PDFArticle Synopsis
- This study analyzes the response of the Brazilian ionosphere to geomagnetic storms driven by Corotating Interaction Regions (CIR) and High-Speed Solar Wind Streams (HSS) during 2016-2017.
- It investigates Vertical Total Electron Content (VTEC) variations across three regions: equatorial, northern crest, and southern crest of the Equatorial Ionization Anomaly, noting both enhancements and depletions of up to 30 and 20 TECu, respectively.
- The research also highlights the timing of these variations, the role of electric fields in the ionosphere, and includes new catalogs for low-latitude ionospheric storms useful for space weather and modeling.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!