The expression of a cell proliferation-associated human nuclear antigen was immunohistochemically studied in human anagen hair and hair follicles using the monoclonal antibody Ki-67. The reaction of Ki-67 in mature anagen hair follicles was observed in the hair matrix cells and outer root sheath (ORS) cells. Nuclear staining was seen in a small number of matrix cells and in some ORS cells; this finding corresponded to the thymidine or bromodeoxyuridine labeling studies previously reported. In addition, there were two different patterns of cytoplasmic staining in the ORS: strong staining of the innermost cells (IMC) and weaker staining of the other ORS cells in the isthmus. Ki-67 reactivity of the IMC layer was observed at each stage of anagen and was regularly seen from the upper bulb to the isthmus. Ki-67 is a commercially available antibody that detects cycling cells. However, the IMCs in anagen hair follicles showed cytoplasmic labeling by Ki-67 from the matrix cells in the upper bulb to the distal portion of the isthmus.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/1523-1747.ep12555483 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dahuang-Gancao Decoction Ameliorates Testosterone-Induced Androgenetic Alopecia in Mice.
J Ethnopharmacol
January 2025
Eye School of Chengdu University of Traditional Chinese Medicine. Ineye Hospital of Chengdu University of Traditional Chinese Medicine, KeyLaboratory of Sichuan Province Ophthalmopathy Prevention & Cureand Visual Function Protection with Traditional Chinese Medicine Laboratory. Electronic address:
Ethnopharmacological Relevance: Dahuang-Gancao decoction (DGD) is a traditional Chinese medicinal formula that is recorded in the Synopsis of the Golden Chamber, and is widely used to treat damp-heat in the body. Since the pathological factors of androgenetic alopecia (AGA) also reflect damp-heat blockage, DGD has great potential for the treatment of AGA and has been used effectively in clinical practice.
Aim Of The Study: The aim of the study was to investigate whether external application of DGD could promote the activation and proliferation of hair follicle stem cells (HFSCs) and improve AGA through the Wnt/β-catenin pathway.
Unlocking the genetic secrets of Dorper sheep: insights into wool shedding and hair follicle development.
Front Vet Sci
December 2024
College of Animal Science and Technology, Ningxia University, Yinchuan, China.
Dorper sheep is popular among farming enterprises with strong adaptability, disease resistance, and roughage tolerance, and an unique characteristic of natural shedding of wool. In a large number of observations on experimental sheep farms, it was found that the wool of some sheep still had not shed after May, thus manual shearing was required. Therefore, understanding the molecular mechanisms of normal hair follicles (HFs) development is crucial to revealing the improvement of sheep wool-related traits and mammalian skin-related traits.
View Article and Find Full Text PDFThe effect of platelet-derived growth factor-aa (PDGFA) conjugated with low-molecular-weight protamine (LMWP) on hair loss improvement effect.
Biochem Biophys Res Commun
January 2025
Department of Pharmaceutical & Cosmetics, Dongshin University, 185, gunjae-ro, Naju, Jeonnam, 58245, Republic of Korea. Electronic address:
Platelet-derived growth factor-AA (PDGFA) is known to play an important role in hair loss and hair growth by involving in the anagen phase of the hair follicle growth cycle. In this study, we synthesized skin-permeable recombinant low-molecular-weight protamine (LMWP)-conjugated PDGFA (LMWP-PDGFA) by linking LMWP to the N terminus of PDGFA. We evaluated the hair loss improvement effect, wound healing efficacy, and skin permeability of LMWP-PDGFA.
View Article and Find Full Text PDFDiffuse face and ear hypertrichosis caused by 5% topical minoxidil in an adult woman with spontaneous resolution.
Dermatol Online J
August 2024
Dermatology and Dermatologic Surgery Department, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
Minoxidil is a vasodilator medication known for its ability to promote hair growth. Although it was first introduced as an oral drug to treat hypertension, minoxidil was observed to have the important side-effect of increasing hair growth. This led to the development of a topical formulation as a 2% concentration solution for the treatment of female androgenic alopecia (AGA) and 5% for treating male AGA, which is considered as a first line U.
View Article and Find Full Text PDFChronic circadian misalignment is a risk factor for hair growth impairment.
iScience
October 2024
The Research Institute for Time Studies, Yamaguchi University, 1677-1 Yoshida, Yamaguchi, Yamaguchi, Japan.
To identify environmental factors that accelerate hair loss, we focused on modern artificial and aberrant light environments which cause circadian dysfunction. We examined the effect of aberrant light environments on hair growth by exposing mice to repetitive light-dark reversal at three-day intervals, inducing chronic circadian misalignment. Dorsal hair-sheared male mice showed impaired hair growth under this light condition.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!