AI Article Synopsis
- The study aimed to assess how effective a controlled slow-release GM-CSF system is in healing burn wounds.
- 18 Wistar-Albino rats were used, divided into three groups to compare the effects of burn treatment: one group received no treatment, another received chitosan gel, and the third received chitosan gel plus GM-CSF.
- Results showed that the group treated with the controlled slow-release GM-CSF had the best healing outcomes, with significantly reduced wound areas.
- The conclusion highlighted that single-dose GM-CSF from chitosan gel can positively enhance burn wound healing.
Article Abstract
Objective: The aim of the study is to investigate the effectiveness of the controlled slow-release granulocyte-monocyte colony-stimulating factor (GM-CSF) system in burn wound healing.
Material And Methods: In vivo effect of controlled slow-release GM-CSF from chitosan gel on burn wound healing was evaluated on 18 Wistar-Albino rats, weighing between 250 and 300 g. They were randomly divided into 3 groups; (1) burned only group (n = 6), (2) burned + chitosan group (n = 6), (3) burned + chitosan + GM-CSF group (n = 6). Wound area was measured macroscopically. Hematoxylin and eosin and Masson's trichrome stained sections were evaluated for wound healing and tissue response to the polymer.
Results: The best healing process was observed with the controlled slow-release GM-CSF-applied group (group 3) in which the wound area was significantly narrowed.
Conclusion: The study demonstrated the positive contribution of the single-dose controlled slow-release GM-CSF from chitosan gel on burn wound healing.
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| http://dx.doi.org/10.1097/SAP.0b013e31822af865 | DOI Listing |
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