Are subinhibitory concentrations of antibiotics the only culprit of antibiotic resistance?

Evaluation of: Gullberg E, Cao S, Berg OG et al. Selection of resistant bacteria at very low antibiotic concentrations. PLoS Pathog. 7(7), e1002158 (2011). Subinhibitory concentrations of antibiotics and antifungals promote resistance. Antibiotic consumption including hospital use, and country use, including patients self-medications is one of the major drivers of antibiotic or antifungal resistance. However, consumption of antibiotics should be distinguished between the hospital and community. Hospital consumption, poor hospital hygiene and intrahospital transfer have been determined as major risk factors for development of resistance. The correlation between resistance and consumption in the community is not so clear. Therefore consumption of antibiotics and antifungals alone cannot explain the selection of resistant bacterial and fungal mutants and other factors have to be investigated.