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Kaempferol modulates Wnt/ β-catenin pathway to alleviate preeclampsia- induced changes and protect renal and ovarian histomorphology.
J Mol Histol
December 2024
Department of Obstetrics, Yantaishan Hospital, Yantai, Shandong, 264003, China.
Preeclampsia (PE) is a form of hypertension that manifests in the later stages of pregnancy. Since Kaempferol (Ka) has remedial potential hence this research was conducted to examine its therapeutic effect on Preeclampsia rats by regulating Wingless-related integration site/β-catenin (Wnt/B-catenin) pathway. To achieve this, thirty-two SD female rats were randomly allocated into four groups: control, preeclampsia (PE, LPS, 1 mg/kg), preeclampsia with kaempferol (PE + Ka), and preeclampsia with Dickkopf - 1 (DKK-1) and kaempferol (PE + DKK-1 + Ka).
View Article and Find Full Text PDFdeletion increases osteoblast maturation and bone mass accrual in adult male mice.
JBMR Plus
October 2024
Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN 55905, United States.
Osteoporosis and other metabolic bone diseases are prevalent in the aging population. While bone has the capacity to regenerate throughout life, bone formation rates decline with age and contribute to reduced bone density and strength. Identifying mechanisms and pathways that increase bone accrual in adults could prevent fractures and accelerate healing.
View Article and Find Full Text PDFEnhancing motor functional recovery in spinal cord injury through pharmacological inhibition of Dickkopf-1 with BHQ880 antibody.
Biomed Pharmacother
July 2024
Laboratory of Molecular Neurology, Fundación Hospital Nacional de Parapléjicos Para la Investigación y la Integración, Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), Carretera Finca la Peraleda, s/n, Toledo 45071, Spain; Laboratory of Molecular Neurology, Hospital Nacional de Parapléjicos, SESCAM, Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), Carretera Finca la Peraleda, s/n, Toledo 45071, Spain. Electronic address:
Background: Mounting experimental evidence has underscored the remarkable role played by the Wnt family of proteins in the spinal cord functioning and therapeutic potential in spinal cord injury (SCI). We aim to provide a therapeutic prospect associated with the modulation of canonical Wnt signaling, examining the spatio-temporal expression pattern of Dickkopf-1 (Dkk1) and its neutralization after SCI. We employ an intraparenchymal injection of the clinically validated Dkk1-blocking antibody, BHQ880, to elucidate its effects in SCI.
View Article and Find Full Text PDFBiomarkers of disability worsening in inactive primary progressive multiple sclerosis.
J Neuroimmunol
February 2024
Department of Clinical Neurosciences, University of Calgary, Canada; Hotchkiss Brain Institute, University of Calgary, Canada. Electronic address:
Objective: To investigate serum biomarkers of progression in inactive primary progressive multiple sclerosis (PPMS).
Methods: We measured protein biomarkers (growth differentiation factor-15 (GDF-15), dickkopf-1 (DKK-1), neuron specific enolase (NSE) and cathepsin-D) in serum samples from 39 patients with inactive PPMS included in a clinical trial enrolling people with PPMS (clinicaltrials.gov identifier NCT02913157) and investigated the association of these biomarker levels with clinical disability at baseline and during follow-up.
Inhibition of a novel Dickkopf-1-LDL receptor-related proteins 5 and 6 axis prevents diabetic cardiomyopathy in mice.
Eur Heart J
March 2024
Innovation and Transformation Center, Collaborative Innovation Center for Rehabilitation Technology, Fujian Key Laboratory of Integrative Medicine on Geriatrics, Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, 1 Qiuyang Road, Minhou, Fuzhou 350122, China.
Background And Aims: Anti-hypertensive agents are one of the most frequently used drugs worldwide. However, no blood pressure-lowering strategy is superior to placebo with respect to survival in diabetic hypertensive patients. Previous findings show that Wnt co-receptors LDL receptor-related proteins 5 and 6 (LRP5/6) can directly bind to several G protein-coupled receptors (GPCRs).
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