AI Article Synopsis
- Intermediate filaments (IF) are one of the three main cytoskeletal systems in vertebrate cells, yet they are the least understood regarding their structure and functions.
- The complexity of IF arises from a large gene family that is regulated based on the developmental stage and specific cell or tissue type.
- This article honors Ueli Aebi and discusses over 40 years of research from the laboratory that has been significantly influenced by discussions with him during various adventurous trips.
Article Abstract
Although intermediate filaments are one of three major cytoskeletal systems of vertebrate cells, they remain the least understood with respect to their structure and function. This is due in part to the fact that they are encoded by a large gene family which is developmentally regulated in a cell and tissue type specific fashion. This article is in honor of Ueli Aebi. It highlights the studies on IF that have been carried out by our laboratory for more than 40 years. Many of our advances in understanding IF are based on conversations with Ueli which have taken place during adventurous and sometimes dangerous hiking and biking trips throughout the world.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269975 | PMC |
| http://dx.doi.org/10.1016/j.jsb.2011.11.017 | DOI Listing |
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