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VDAC is now universally accepted as the channel in the mitochondrial outer membrane responsible for metabolite flux in and out of mitochondria. Its discovery occurred over two independent lines of investigation in the 1970s and 80s. This retrospective article describes the history of VDAC's discovery and how these lines merged in a collaboration by the authors. The article was written to give the reader a sense of the role played by laboratory environment, personalities, and serendipity in the discovery of the molecular basis for the unusual permeability properties of the mitochondrial outer membrane. This article is part of a Special Issue entitled: VDAC structure, function, and regulation of mitochondrial metabolism.
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http://dx.doi.org/10.1016/j.bbamem.2011.11.014 | DOI Listing |
Nat Commun
March 2025
Institute of Biochemistry I, Jena University Hospital - Friedrich Schiller University Jena, Nonnenplan 2-4, 07743, Jena, Germany.
Proper neuronal development, function and survival critically rely on mitochondrial functions. Yet, how developing neurons ensure spatiotemporal distribution of mitochondria during expansion of their dendritic arbor remained unclear. We demonstrate the existence of effective mitochondrial positioning and tethering mechanisms during dendritic arborization.
View Article and Find Full Text PDFAnat Histol Embryol
March 2025
Department of Veterinary Anatomy, College of Veterinary Science, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, India.
This study was conducted on 12 adult pigs of a local mixed breed to examine the histology, histochemistry and ultrastructure of the choroid and retinal pigmented epithelium (RPE). The tissues were fixed in Davidson's Fluid for light microscopy and Karnovsky's fluid for electron microscopy. Due to the physiological, anatomical and metabolic similarities between pigs and humans, pigs are a suitable animal model for various ophthalmic studies.
View Article and Find Full Text PDFRSC Med Chem
February 2025
School of Chemistry, Faculty of Science, The University of Sydney Sydney New South Wales 2006 Australia
The translocator protein (TSPO) is an 18 kDa protein on the outer mitochondrial membrane. It has gained significant interest in recent years for its potential as a therapeutic target and imaging biomarker, particularly in neuroinflammation, cancer, and central nervous system disorders (CNS). Clinical translation of ligands has been complicated by the presence of a common single nucleotide polymorphism (A147T TSPO), at which many disclosed TSPO ligands lose affinity.
View Article and Find Full Text PDFbioRxiv
February 2025
Department of Cell and Developmental Biology, Vanderbilt University, Nashville, United States.
One of the hallmarks of aging is a decline in the function of mitochondria, which is often accompanied by altered morphology and dynamics. In some cases, these changes may reflect macromolecular damage to mitochondria that occurs with aging and stress, while in other cases they may be part of a programmed, adaptive response. In this study, we report that mitochondria undergo dramatic morphological changes in chronologically aged yeast cells.
View Article and Find Full Text PDFMethods Cell Biol
March 2025
Department of Clinical and Molecular Sciences, Marche Polytechnic University, Ancona, Italy; Advanced Technology Center for Aging Research, IRCCS INRCA, Ancona, Italy. Electronic address:
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the principal human pathogens, causing severe infections in skin wounds. MRSA infection triggers a cell response mainly by mitochondrial-mediated pathway, resulting in mitochondrial outer membrane permeabilization, extrusion of the mitochondrial inner membrane into the cytoplasm, and then spillage of mitochondrial DNA (mtDNA) into the cytoplasm. The cell recognizes the discharged cytosolic mtDNA (cmtDNA) as "not-itself" because of mtDNA properties and triggers cascade events, such as the activation of inflammasomes.
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