Three novel alleles at the HLA-DRB1 locus identified by sequence-based typing.

Hum Immunol

Organ and Tissue Transplantation Immunology, Regenerative Medicine Department, Immunologia dei Trapianti di Organi e Tessuti, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy.

Published: January 2012

We describe here the sequences of 3 new HLA-DRB1 variants officially named DRB1*03:05:03, DRB1*11:10:02, and DRB1*14:86. These novel alleles have been detected in 3 Caucasoid individuals by sequence-based typing. The first and second alleles are the result of a silent mutation, which does not imply any amino acid change. The sequence of DRB1*14:86 exhibits a single nucleotide difference with the allele DRB1*14:01:01 at position 239.

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http://dx.doi.org/10.1016/j.humimm.2011.11.004DOI Listing

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