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Hemostasis and thrombosis risks and management in vascular anomalies.
Hematology Am Soc Hematol Educ Program
December 2024
Pediatric Hematology-Oncology, University of Arkansas for Medical Sciences, Little Rock, AR.
The role of the hematologist in the management of vascular anomalies is evolving. Several vascular tumors and malformations are associated with complex coagulation derangements. Kaposiform hemangioendothelioma or tufted angiomas may present with a consumptive coagulopathy known as the Kasabach-Merritt phenomenon (KMP).
View Article and Find Full Text PDFReduction in the olfactory ability in aging mutant mice without evidence of neurodegeneration.
Front Aging
October 2024
Department of Anatomy, Biomedical Center, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Age-related decline occurs in most brain structures and sensory systems. An illustrative case is olfaction. The olfactory bulb (OB) undergoes deterioration with age, resulting in reduced olfactory ability.
View Article and Find Full Text PDFAn autopsy case of progressive supranuclear palsy with severe corticospinal tract degeneration.
Neuropathology
December 2024
Department of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Aichi, Japan.
Article Synopsis
- - A 70-year-old man with atypical progressive supranuclear palsy (PSP) experienced symptoms like gait ataxia, vertical gaze palsy, rigidity, and cognitive issues, with worsening upper motor signs over time.
- - Autopsy findings revealed significant neuronal loss and gliosis in critical brain areas, including the motor cortex and basal ganglia, along with the presence of tufted astrocytes and neurofibrillary tangles.
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Diagnostic features of metastatic endometrioid carcinoma in a captive black-tufted marmoset (Callithrix penicillata).
J Med Primatol
August 2024
Graduate Program in Animal Sciences, University of Brasília, Brasilia, Federal District, Brazil.
A captive marmoset developed metastatic endometrioid carcinoma (EnC), a rare uterine tumor in non-human primates (NHPs). The neoplasm showed marked microscopical malignant and tubulopapillary aspects, immunopositivity for pan-cytokeratin, CK7, estrogen receptor, and a high mitotic index (Ki-67). These features may contribute to the diagnosis and therapeutics of EnC in NHPs.
View Article and Find Full Text PDFPost-mortem diagnosis of human rabies in SARS-CoV-2 coinfected patient with minimally invasive autopsy in northeastern Brazil.
J Infect Dev Ctries
July 2024
Department of Infectious Diseases of Hospital das Clínicas and Laboratório de Investigação Médica - LIM 49, University of São Paulo, São Paulo, Brazil.
Article Synopsis
- Human rabies is a deadly disease caused by lyssaviruses, and there has been an increase in cases following the COVID-19 pandemic.
- A case from Ceará, Brazil in 2023 involved a patient bitten by a marmoset who was also co-infected with SARS-CoV-2, diagnosed using minimally invasive autopsy (MIA).
- MIA is beneficial for its biosafety and efficiency, reducing body disfigurement and enhancing rabies diagnostics and family cooperation in tracking the disease.
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