This article follows the development and progress of the US Department of Housing and Urban Development's 'Healthy and Safe Communities' initiative as it was implemented by a community empowerment organization during a four-year community revitalization project in the aftermath of the Los Angeles riots. The author explores practical aspects of Community Health Psychology through assessing the ways in which its organizing principles were manifest in community-wide processes of individual and community change in one low-income housing project in South Central Los Angeles called Avalon Gardens. Specifically highlighted is how a group of African American and Latino men in the community created a group forum that helped foster, support and sustain an empowerment process that supported health promotion, health consciousness and significant health improvement in the community.
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http://dx.doi.org/10.1177/1359105302007003226 | DOI Listing |
J Nat Prod
February 2025
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093, United States.
A structurally novel metabolite, fatuamide A (), was discovered from a laboratory cultured strain of the marine cyanobacterium sp., collected from Faga'itua Bay, American Samoa. A bioassay-guided approach using NCI-H460 human lung cancer cells directed the isolation of fatuamide A, which was obtained from the most cytotoxic fraction.
View Article and Find Full Text PDFNucleic Acids Res
January 2025
Bioinformatics Group, Wageningen University & Research, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands.
Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is governed by sets of co-regulated and physically clustered genes known as biosynthetic gene clusters (BGCs). To share information about BGCs in a standardized and machine-readable way, the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard and repository was initiated in 2015.
View Article and Find Full Text PDFJ Nat Prod
June 2024
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
Kavaratamide A (), a new linear lipodepsipeptide possessing an unusual isopropyl--methylpyrrolinone moiety, was discovered from the tropical marine filamentous cyanobacterium collected from Kavaratti, India. A comparative chemogeographic analysis of . collected from six different geographical regions led to the prioritized isolation of this metabolite from India as distinctive among our data sets.
View Article and Find Full Text PDFCureus
March 2024
Emergency Medicine, All India Institute of Medical Sciences, New Delhi, IND.
ACS Chem Biol
March 2024
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
The tropical marine cyanobacterium JHB is a prolific source of secondary metabolites with potential biomedical utility. Previous studies on this strain led to the discovery of several novel compounds such as hectochlorins and jamaicamides. However, bioinformatic analyses of its genome indicate the presence of numerous cryptic biosynthetic gene clusters that have yet to be characterized.
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