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Integrating 16S rDNA and metabolomics to uncover the therapeutic mechanism of electroacupuncture in type 2 diabetic rats.
Front Microbiol
January 2025
School of Acupuncture-Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Objective: This study aimed to investigate the impact of electroacupuncture (EA) on blood glucose levels, gut microbiota, short-chain fatty acids (SCFAs), and glucagon-like peptide-1 (GLP-1) in a rat model of type 2 diabetes mellitus (T2DM).
Methods: Forty Sprague-Dawley (SD) rats were randomly assigned to five groups (n = 8/group) using a random number table: normal control, T2DM model, electroacupuncture (EA), EA + antibiotics (EA + A), and antibiotics (A). The normal rats received a standard diet and saline gavage, while the other groups were fed a high-fat diet and emulsion.
Downregulation of CCR2 reduces ventricular remodeling after myocardial infarction by splenic nerve neuromodulation in acute and chronic rat models.
Int Immunopharmacol
January 2025
Department of Cardiovascular Medicine, Fifth Affiliated Hospital of Sun Yat-sen University, Zhu Hai 519000 PR China; Guangdong Provincial Engineering Research Center of Molecular Imaging, Fifth Affiliated Hospital of Sun Yat-sen University, Zhu Hai 519000 PR China. Electronic address:
Objectives: Pathological remodeling after myocardial infarction (MI) confers the development of heart failure. Our prior research has indicated that splenic nerve neuromodulation mitigates myocardial ischemia-reperfusion injury (IRI) by reducing levels of proinflammatory factors. This study aims to explore the potential therapeutic benefits of splenic nerve neuromodulation in MI and the underlying mechanism.
View Article and Find Full Text PDFEffect and regulatory mechanism of SIRT6 on post-cardiac arrest brain injury in rats.
Shock
December 2024
Department of Emergency Medicine, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430074, China.
Aims: Brain injury occupies the predominant cause of neurological dysfunction and mortality after successful cardiopulmonary resuscitation (CPR) from cardiac arrest (CA). This study investigates the role and mechanism of Sirtuin 6 (SIRT6) in post-cardiac arrest brain injury in rats.
Methods: All rats were subjected to asphyxial CA followed by CPR.
Liuwei Anshen Capsule alleviates cognitive impairment induced by sleep deprivation by reducing neuroapoptosis and inflammation.
J Ethnopharmacol
December 2024
Engineering Research Center of TCM Protection Technology and New Product Development for the Elderly Brain Health, Ministry of Education, Hubei University of Chinese Medicine, Wuhan, 430065, China; Key Laboratory of Chinese Medicine Resource and Compound Prescription, Ministry of Education, Hubei University of Chinese Medicine, Wuhan, 430065, China. Electronic address:
Article Synopsis
- Cognitive dysfunction is a common issue linked to chronic insomnia, and Liuwei Anshen Capsules (LAC) have shown promise in alleviating insomnia-related complications like dementia and anxiety, although their active compounds and mechanisms are not fully understood.
- The study aims to identify the active ingredients in LAC and their effects on cognitive impairment due to sleep deprivation, utilizing methods such as serum pharmacochemistry, network pharmacology, and experimental validation.
- Results indicated that LAC contains 85 active ingredients, with several key targets and pathways identified, and it successfully improved cognitive function in sleep-deprived rats while regulating several proteins and inflammatory markers, suggesting its therapeutic potential.
Minimal presynaptic protein machinery governing diverse kinetics of calcium-evoked neurotransmitter release.
Nat Commun
December 2024
Nanobiology Institute, Yale University, West Haven, CT, USA.
Neurotransmitters are released from synaptic vesicles with remarkable precision in response to presynaptic calcium influx but exhibit significant heterogeneity in exocytosis timing and efficacy based on the recent history of activity. This heterogeneity is critical for information transfer in the brain, yet its molecular basis remains poorly understood. Here, we employ a biochemically-defined fusion assay under physiologically relevant conditions to delineate the minimal protein machinery sufficient to account for various modes of calcium-triggered vesicle fusion dynamics.
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