The reverse of polymer degradation: in situ crosslinked gel formation through disulfide cleavage.

Chem Commun (Camb)

Network of Excellence for Functional Biomaterials, National University of Ireland Galway, IDA Business Park, Galway, Ireland.

Published: January 2012

In contrast to the usual inclusion of disulfide bonds within a polymer structure to facilitate bio-degradation, we have designed a self-curing "one pot" hyperbranched polymer capable of forming crosslinked gels under reducing conditions abundant in tumoural tissue.

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Source
http://dx.doi.org/10.1039/c1cc16538kDOI Listing

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