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Non-motor asymmetry and dopamine degeneration in Parkinson's disease.
Brain Commun
January 2025
Department of Clinical Medicine, Aarhus University Hospital, Aarhus N, 8200 Aarhus, Denmark.
Asymmetric dopaminergic degeneration of the striatum is a characteristic feature of Parkinson's disease, associated with right-left asymmetry in motor function. As such, studying asymmetry provides insights into progressive neurodegeneration between cerebral hemispheres. Given the impact of Lewy pathology on various neurotransmitter systems beyond the dopaminergic, it may be that other neuronal systems in the predominantly affected hemisphere are similarly affected.
View Article and Find Full Text PDFValidity and reliability of local endemic language version of the SARI Sigma Scale questionnaire for assessing stigma in leprosy patients.
Front Public Health
January 2025
Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
Introduction: The Stigma Assessment and Reduction of Impact (SARI) Stigma Scale is an instrument developed to evaluate stigma in Leprosy patients. Despite existing versions in Indonesian, the absence of an endemic area language version of a reliable assessment tool presents a barrier to effective interventions in regions like Ambon. This study aims to evaluate the validity and reliability of the Ambonese-Malay Language of SARI Stigma Scale questionnaire.
View Article and Find Full Text PDFYoung people's experiences of informal kinship care in Luwero, Uganda.
Child Youth Serv Rev
April 2024
London School of Hygiene & Tropical Medicine (LSHTM), United Kingdom.
There is strong evidence that outside parental care, informal kinship care is the most practiced, sustainable and affordable form of childcare in SSA (sub-Saharan Africa). As a longstanding cultural tradition, informal kinship care embraces childcare as the responsibility of all extended family members, and often the wider community. However, over the past decades, informal kinship care has become gradually strained by political, economic and social conditions, such as: legacies of colonialism, increasing levels of poverty and inequality, instability, or infectious diseases.
View Article and Find Full Text PDFSynergistic interaction between wheat streak mosaic virus and Triticum mosaic virus modulates wheat transcriptome to favor disease severity.
Front Plant Sci
January 2025
Department of Plant Pathology, University of Nebraska-Lincoln, Lincoln, NE, United States.
Wheat streak mosaic virus (WSMV; ) and Triticum mosaic virus (TriMV; ), the type members of the genera and , respectively, in the family , are economically important wheat viruses in the Great Plains region of the USA. Co-infection of wheat by WSMV and TriMV results in disease synergism. Wheat transcriptome from singly (WSMV or TriMV) and doubly (WSMV+TriMV) infected upper uninoculated leaves were analyzed by RNA-Seq at 9, 12, and 21 days postinoculation.
View Article and Find Full Text PDFPredictors of complicated appendicitis among patients presented to public referral hospitals in Harari region, Eastern Ethiopia: a case-control study.
Surg Pract Sci
June 2022
Department of Nursing, School of Nursing and Midwifery, College of Health and Medical Science, Haramaya University, Harar, Ethiopia.
Background: Complicated appendicitis makes up a significant proportion of acute appendicitis. There are well established associated factors for the development of complications, but the magnitude varies between developed and developing countries. This study was aimed to look for possible incriminated factors for higher rate of complicated appendicitis among patients treated in public hospitals found in the Harari region, Eastern Ethiopia.
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