AI Article Synopsis
- The review explores how pressure overload on the heart leads to ventricular hypertrophy as a compensatory mechanism to manage increased stress on the walls of the heart.
- Although ventricular hypertrophy initially helps, it involves changes that can negatively affect heart function over time, potentially resulting in heart failure.
- The text highlights specific molecular mechanisms that drive hypertrophy and can lead to harmful structural changes in the heart, increasing the risk of serious cardiac issues.
Article Abstract
This review discusses cardiac consequences of pressure overload. In response to elevated pressure, the ventricular hypertrophy compensates for the increased wall stress. However, the ventricular hypertrophy involves numerous structural adaptations that may lead to ventricular dysfunction and, eventually, heart failure. Particular emphasis is placed on molecular mechanisms that govern the development of hypertrophy and that may lead to maladaptive structural changes resulting in adverse cardiac events.
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Source |
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| http://dx.doi.org/10.1016/j.hfc.2011.08.005 | DOI Listing |
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