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Management of Horizontal Cleavage Meniscus Tears.
Curr Rev Musculoskelet Med
December 2024
Department of Orthopaedics, The Ohio State University Wexner Medical Center, 2835 Fred Taylor Dr. Suite 2200, Columbus, OH, 43202, USA.
Purpose Of Review: The management of horizontal cleavage meniscus tears (HCT) has evolved in recent years. Historically, HCTs have been treated with partial meniscectomy, but multiple studies have shown the long-term risks of development of arthritic changes in the knee following meniscectomy. These findings have renewed interest in meniscal preservation whenever possible, even in older patients not previously considered for meniscus repair.
View Article and Find Full Text PDFAcute systemic macrophage depletion in osteoarthritic mice alleviates pain-related behaviors and does not affect joint damage.
Arthritis Res Ther
December 2024
Department of Internal Medicine, Division of Rheumatology, Rush University Medical Center, Chicago, IL, USA.
Background: Osteoarthritis (OA) is a painful degenerative joint disease and a leading source of years lived with disability globally due to inadequate treatment options. Neuroimmune interactions reportedly contribute to OA pain pathogenesis. Notably, in rodents, macrophages in the DRG are associated with onset of persistent OA pain.
View Article and Find Full Text PDFArthroscopic meniscal surgery in Norway from 2010 to 2020: A paradigmatic shift.
J Exp Orthop
October 2024
Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences NTNU Trondheim Norway.
Purpose: Meniscal injuries in the knee are usually treated surgically with arthroscopic partial resection (APR) or arthroscopic repair (AR). APR has been shown to increase the risk of osteoarthritis and the focus has shifted to repairing the meniscus with AR. The extent of this shift is yet to be established and an analysis of incidence rates (IR) of APR and AR for meniscal injuries could highlight this.
View Article and Find Full Text PDFArticle Synopsis
- LASIK surgery can cause temporary dry eye due to nerve damage, but this study investigates long-term ocular surface changes, blinking rates, and meibomian gland health in post-LASIK patients at least 48 months post-surgery.
- The study involved 48 post-LASIK patients and 48 matched healthy controls, assessing clinical findings and imaging related to eye health.
- Findings showed that post-LASIK patients had lower meibum quality, reduced tear production, and high chronic dry eye symptom prevalence, indicating the need for thorough evaluations and treatments for affected patients.
The Therapeutic Potential of Pristimerin in Osteoarthritis: Mechanistic Insights from in vitro and in vivo Studies.
Drug Des Devel Ther
December 2024
Department of Sports Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, 310000, People's Republic of China.
Objective: Osteoarthritis (OA), a degenerative disease marked by cartilage erosion and synovial proliferation, has led to an increased interest in natural plant-based compounds to slow its progression. Pristimerin(Pri), a triterpenoid compound derived from Tripterygium wilfordii, has demonstrated anti-inflammatory and antioxidant characteristics. This study explores the protective effects of Pri on OA and its potential mechanisms.
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