Using a simple two step fabrication process substrates with a large and uniform Raman enhancement, based on flexible free standing nanopillars can be manufactured over large areas using readily available silicon processing equipment.
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Genetic predisposition of metabolic dysfunction-associated steatotic liver disease: a population-based genome-wide association study.
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Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Background/purpose: Although metabolic dysfunction-associated steatotic liver disease (MASLD) has been proposed to replace the diagnosis of non-alcoholic fatty liver disease (NAFLD) with new diagnostic criteria since 2023, the genetic predisposition of MASLD remains to be explored.
Methods: Participants with data of genome-wide association studies (GWAS) in the Taiwan Biobank database were collected. Patients with missing data, positive for HBsAg, anti-HCV, and alcohol drinking history were excluded.
Advancements in microalgal biomass conversion for rubber composite applications.
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Hydrobiology Lab, Water Pollution Research Department, National Research Centre, Dokki, Giza, 12622, Egypt.
Carbon black (CB) as rubber reinforcement has raised environmental concerns regarding this traditional petroleum-based filler, which is less susceptible to biodegradability. Although it has great reinforcing properties, the production technique is no longer sustainable, and its cost increases regularly. For these reasons, it is wise to look for sustainable replacement materials.
View Article and Find Full Text PDFUltrasensitive detection and quantification of bovine Deltapapillomavirus in the semen of healthy horses.
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Dipartimento di Medicina Veterinaria e delle Produzioni Animali, Università degli Studi di Napoli Federico II, Naples, Italy.
BPV1, BPV2, BPV13, and BPV14 are all genotypes of bovine delta papillomaviruses (δPV), of which the first three cause infections in horses and are associated with equine sarcoids. However, BPV14 infection has never been reported in equine species. In this study, we examined 58 fresh and thawed commercial semen samples from healthy stallions.
View Article and Find Full Text PDFPrediction of pulmonary embolism by an explainable machine learning approach in the real world.
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Department of Respiratory and Critical Care Medicine, Changhai Hospital, The Second Military Medical University, Shanghai, People's Republic of China.
In recent years, large amounts of researches showed that pulmonary embolism (PE) has become a common disease, and PE remains a clinical challenge because of its high mortality, high disability, high missed and high misdiagnosed rates. To address this, we employed an artificial intelligence-based machine learning algorithm (MLA) to construct a robust predictive model for PE. We retrospectively analyzed 1480 suspected PE patients hospitalized in West China Hospital of Sichuan University between May 2015 and April 2020.
View Article and Find Full Text PDFDOME: Directional medical embedding vectors from electronic health records.
J Biomed Inform
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Harvard Medical School, Boston, MA, USA; VA Boston Healthcare System, Boston, MA, USA; Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address:
Motivation: The increasing availability of electronic health record (EHR) systems has created enormous potential for translational research. Recent developments in representation learning techniques have led to effective large-scale representations of EHR concepts along with knowledge graphs that empower downstream EHR studies. However, most existing methods require training with patient-level data, limiting their abilities to expand the training with multi-institutional EHR data.
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