Fluorescent combination: Cell-penetrating probes derived from the diterpene fusicoccin can form ternary complexes with 14-3-3 proteins and phosphopeptide ligands, whereupon the probes site-specifically attach a fluorescent tag onto the surface of the 14-3-3 proteins.
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http://dx.doi.org/10.1002/anie.201106995 | DOI Listing |
Sci Rep
December 2024
Department of Earth Sciences, University of Oxford, South Parks Rd, Oxford, OX1 3AN, UK.
Coccolithophores comprise a major component of the oceanic carbon cycle. These unicellular algae produce ornate structures made of calcium carbonate, termed coccoliths, representing ~ 50% of calcite production in the open ocean. The exact molecular mechanisms which direct and control coccolith formation are unknown.
View Article and Find Full Text PDFTrends Microbiol
December 2024
Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insect Pests, Institute of Biotechnology, Zhejiang University, Hangzhou 310058, China; Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province, Institute of Biotechnology, Zhejiang University, Hangzhou 310058, China; National Key Laboratory for Rice Biology and Breeding, Institute of Biotechnology, Zhejiang University, Hangzhou 310058, China. Electronic address:
Protein PARylation is a reversible post-translational modification; however, its role in fungal virulence has remained elusive. Recently, Gao et al. demonstrated that PARylation of two 14-3-3 regulatory proteins by poly(ADP-ribose) polymerase is essential for the virulence of rice blast fungus, highlighting the critical regulatory function of PARylation in fungal pathogenicity.
View Article and Find Full Text PDFFront Mol Biosci
December 2024
Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow, India.
J Neurol
December 2024
The UK National CJD Research and Surveillance Unit, Centre for Clinical Brain Sciences, Chancellor's Building, University of Edinburgh, Edinburgh, EH16 4TG, UK.
Background: Sporadic Creutzfeldt-Jakob disease (sCJD) is a rapidly progressive and fatal prion disease with significant public health implications. Survival is heterogenous, posing challenges for prognostication and care planning. We developed a survival model using diagnostic data from comprehensive UK sCJD surveillance.
View Article and Find Full Text PDFInt J Biol Sci
December 2024
College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
FOXO proteins, especially FOXO1 and FOXO3, are recognized for their roles in controlling apoptosis and autophagy. Both apoptosis and autophagy have been induced in granulosa cells (GCs) by hypoxic conditions in ovarian follicles; however, the exact contribution of FOXO proteins and autophagy to the regulation of GCs apoptosis under hypoxia remains unclear. In this investigation of porcine GCs, we reveal that FOXO1 promotes apoptosis in response to hypoxia through FOXO3-dependent autophagy.
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