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Grouping of chemicals for safety assessment: the importance of toxicokinetic properties of salicylate esters.
Arch Toxicol
January 2025
Cosmetics Europe, Brussels, Belgium.
Grouping of chemicals has been proposed as a strategy to speed up the screening and identification of potential substances of concern among the broad chemical universe under REACH. Such grouping is usually based on shared structural features and should only be used for the prioritization objectives. However, additional considerations (as well as structural similarity) are needed, e.
View Article and Find Full Text PDFIdentification of channel shifting patterns and bank erosion-prone sites and challenges of riverine livelihood in the lower Tista River basin.
Environ Sci Pollut Res Int
January 2025
Department of Geography, Rampurhat College, PO-Rampurhat, Dist-Birbhum, 731224, India.
In fluvial environments, the shifting of river channels and bank erosion are frequently caused by both natural and anthropogenic factors. Riverine hazards like bank erosion and course alterations offer severe issues to the riparian villages along the lower basin of the Tista River in India, which substantially influence the livelihoods of inhabitants living there. This research addressed river channel shifting tendency and identified major bank erosion-prone villages along the lower course of the Tista River and challenges to the livelihoods of the riparian people.
View Article and Find Full Text PDFInvestigating proteogenomic divergence in patient-derived xenograft models of ovarian cancer.
Sci Rep
January 2025
Department of Laboratory Medicine and Pathology, University of Minnesota School of Medicine, 420 Delaware St SE, MMC 609, Minneapolis, MN, 55455, USA.
Within ovarian cancer research, patient-derived xenograft (PDX) models recapitulate histologic features and genomic aberrations found in original tumors. However, conflicting data from published studies have demonstrated significant transcriptional differences between PDXs and original tumors, challenging the fidelity of these models. We employed a quantitative mass spectrometry-based proteomic approach coupled with generation of patient-specific databases using RNA-seq data to investigate the proteogenomic landscape of serially-passaged PDX models established from two patients with distinct subtypes of ovarian cancer.
View Article and Find Full Text PDFMeasuring the uptake of clinic-based HIV treatment and prevention services following HIV testing and referral at private pharmacies in Kenya.
BMC Health Serv Res
January 2025
Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, USA.
Background: Despite their ubiquity across sub-Saharan Africa, private pharmacies are underutilized for HIV service delivery beyond the sale of HIV self-test kits. To understand what uptake of HIV prevention and treatment services might look like if private pharmacies offered clients free HIV self-testing and referral to clinic-based HIV services, we conducted a pilot study in Kenya.
Methods: At 20 private pharmacies in Kisumu County, Kenya, pharmacy clients (≥ 18 years) purchasing sexual health-related products (e.
Triglyceride-glucose index as a predictor of cardiovascular events in psoriatic patients on systemic therapy: A 150-patient observational study.
Actas Dermosifiliogr
January 2025
Unidad de Salud Pública y Atención Ambiental, Departamento de Medicina Preventiva y Salud Pública, Ciencias de los Alimentos, Toxicología y Medicina Forense, Universidad de Valencia, España; CIBER en Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, España.
Psoriasis is consistently associated with an elevated cardiovascular risk. However, biochemical parameters are needed to predict cardiovascular events in these patients. Therefore, we conducted a retrospective cohort study with psoriatic patients undergoing systemic treatment to analyze the value of the triglyceride-glucose (TyG) index in predicting the development of major adverse cardiovascular events (MACE).
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