The Th17 cells, identified recently as a novel CD4⁺ T cell lineage, are characteristic of their production of IL-17 and distinct from Th1 and Th2 lineages. Their involvement in autoimmune and chronic inflammation diseases has been well observed. Recent evidence suggests that Th17 cells are also involved in tumor immunology. However, it remains unclear that how these cells regulate immune responses to tumor growth. In this review, we summarize the most recent findings about the biologics of the Th17 cells in tumor development with a hope of providing new insights into future development of effective new cancer immunotherapies.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999992 | PMC |
| http://dx.doi.org/10.3779/j.issn.1009-3419.2011.11.10 | DOI Listing |
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