Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1610-0387.2011.07661_suppl.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Expanding the phenotypic spectrum of NAA10-related neurodevelopmental syndrome and NAA15-related neurodevelopmental syndrome.
Eur J Hum Genet
July 2023
George A. Jervis Clinic, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA.
Article Synopsis
- Amino-terminal acetylation (NTA) is a crucial modification affecting approximately 80% of cytosolic proteins in humans, with NAA10 and NAA15 genes playing key roles in this process.
- This study uncovers genetic variations in NAA10 and NAA15, analyzing 106 cases for NAA10 and 66 for NAA15, showing significant clinical and functional differences between individuals with these variants.
- The resultant phenotypic spectrum includes various disabilities and health issues, such as intellectual disabilities, autism, and visual impairments, highlighting the broad impact of disturbances in the NTA pathway across multiple organ systems.
PERFORM: a non-interventional study assessing the patients' treatment starting with 1L palbociclib in HR+/HER2- ABC.
Future Oncol
November 2022
University Hospital Würzburg, Josef-Schneider-Str. 4, Würzburg, 97080, Germany.
The prospective, non-interventional PERFORM study describes and analyzes the effectiveness of palbociclib in combination with endocrine therapy (aromatase inhibitor or fulvestrant) as first-line treatment for patients with locally advanced or metastatic HR+/HER2- breast cancer in the real-world setting in Germany and Austria. PERFORM will reflect current patient characteristics and routine treatment patterns including treatment sequences and time to subsequent (chemo)therapy. Besides, second-line treatment effectiveness and patient-relevant end points such as longitudinal patient-reported outcome measurements beyond disease progression will be analyzed.
View Article and Find Full Text PDFGuidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
Autophagy
January 2021
Hong Kong Baptist University, School of Chinese Medicine, Hong Kong, China.
Article Synopsis
- In 2008, guidelines were established for researching autophagy, which has since gained significant interest and new technologies, necessitating regular updates to monitoring methods across various organisms.
- The new guidelines emphasize selecting appropriate techniques to evaluate autophagy while noting that no single method suits all situations; thus, a combination of methods is encouraged.
- The document highlights that key proteins involved in autophagy also impact other cellular processes, suggesting genetic studies should focus on multiple autophagy-related genes to fully understand these pathways.
Indirect comparisons of ixekizumab versus three interleukin-23 p19 inhibitors in patients with moderate-to-severe plaque psoriasis - efficacy findings up to week 12.
J Dermatolog Treat
February 2022
Institute and Comprehensive Center for Inflammation Medicine, University of Lübeck, Lübeck, Germany.
Background: It is challenging to select the most appropriate biologic treatment for patients with moderate-to-severe plaque psoriasis.
Objective: To compare speed of onset and level of skin improvement between the interleukin (IL)-17A antagonist ixekizumab and the IL-23 p19 inhibitors guselkumab, tildrakizumab, and risankizumab in patients with moderate-to-severe plaque psoriasis.
Methods: Using data from controlled clinical trials, both adjusted indirect comparisons (AICs) and matching adjusted indirect comparisons (MAICs) were performed to determine the risk difference (RD) between ixekizumab and each IL-23 p19 inhibitor for the proportion of patients with ≥75%/90%/100% improvement compared with baseline in Psoriasis Area and Severity Index (PASI 75/90/100) up to week 12.
New seriated Amathia species in Japan, with a redescription of A. acervata Lamouroux, 1824 (Bryozoa: Ctenostomata).
Zootaxa
February 2020
School of Marine Biosciences, Kitasato University, 1-15-1 Kitasato, Minami, Sagamihara, Kanagawa 252-0373, Japan..
The status of seriated Amathia species (Bryozoa: Ctenostomata) in Japan is reviewed. Several historical specimens and materials recently collected from several localities along the Japanese coast are examined in this study. Amathia acervata Lamouroux, 1824, collected from Japan by Wilhelm Gottlieb Tilesius in 1804, was examined and is redescribed from a reconstituted fragment of the sole type specimen.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!