We investigated the hypothesis that lead poisoning was the cause of the clinical syndrome of clenched feet paralysis and leg paresis in wild raptors. Swamp Harriers (Circus approximans) are one of three extant native raptor species in New Zealand. Harriers with the syndrome were found to have statistically significantly higher blood lead concentrations than those without clenched feet (t-test; t=-4.06, df=5, P=0.01). However, elevated blood lead concentrations were also present in 60% of wild harriers without the clinical syndrome of clenched feet paralysis and leg paresis. There were features of the response to chelation treatment, electroneurodiagnostics, and pathology that were inconsistent with lead poisoning as reported in other birds of prey. We conclude that lead may be a factor in the expression of this clinical syndrome of clenched claw paralysis but that other factors not identified in our study play a role in the expression of the disease.
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http://dx.doi.org/10.7589/0090-3558-47.4.907 | DOI Listing |
Taiwan J Obstet Gynecol
November 2024
Department of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan.
Arch Clin Cases
October 2024
Department of Internal Medicine, Monmouth Medical Center, Long Branch, NJ, USA.
Int J Surg Case Rep
December 2024
Port of Spain General Hospital, Port of Spain, Trinidad and Tobago.
Front Genet
September 2024
Beijing Chigene Translational Medical Research Center, Beijing, China.
Introduction: Activating Signal Cointegrator 1 Complex, Subunit 3 () has been implicated in the pathogenesis of neurodevelopmental disorders and neuromuscular diseases (MIM: 620700). This paper analyzes the clinical manifestations of three patients with developmental delay caused by genetic variation. Additionally, we discuss the previously reported clinical features of these patients along with our own findings, thereby enhancing our understanding of these genetic disorders and providing valuable insights into diagnosis, treatment, and potential interventions for affected individuals.
View Article and Find Full Text PDFAnn Med Surg (Lond)
September 2024
Nepalese Army Institute of Health Sciences, Kathmandu.
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