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Indoxyl Sulfate Induces Ventricular Arrhythmias Attenuated by Secretoneurin in Right Ventricular Outflow Tract Cardiomyocytes.
Cardiovasc Toxicol
January 2025
Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, No. 250, Wuxing St., Taipei, 11031, Taiwan.
Ventricular arrhythmias (VAs) are major causes of sudden cardiac death in chronic kidney disease (CKD) patients. Indoxyl sulfate (IS) is one common uremic toxin found in CKD patients. This study investigated whether IS could induce VAs via increasing right ventricular outflow tract (RVOT) arrhythmogenesis.
View Article and Find Full Text PDFClinical impact of diastolic dysfunction and atrial fibrillation before and after initiating hemodialysis in patients with end-stage kidney disease.
Ren Fail
December 2024
Department of Medicine, Division of Nephrology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Background: Diastolic dysfunction with left ventricular hypertrophy and myocardial fibrosis is an important characteristic of uremic cardiomyopathy in end-stage kidney disease (ESKD). Few studies explored the relationship between changes in diastolic dysfunction and the risk of mortality or cardiovascular outcome in patients with ESKD. We investigated the clinical impact of diastolic dysfunction and atrial fibrillation (AF) on patients starting hemodialysis (HD).
View Article and Find Full Text PDFAdvanced Interatrial Block across the Spectrum of Renal Function.
Medicina (Kaunas)
June 2024
Cardiology Unit, Department of Medical Translational Sciences, University of Campania "Luigi Vanvitelli", Monaldi Hospital, Via Leonardo Bianchi, 80126 Naples, Italy.
: Interatrial block (IAB) is defined as a conduction delay between the right and left atria. No data are available about the prevalence of both partial IAB and advanced IAB among the different stages of chronic kidney disease. The aim of this study was to describe the prevalence and type of advanced IAB across the spectrum of renal function, including patients on dialysis and the clinical characteristics associated with advanced IAB.
View Article and Find Full Text PDFAccelerated idioventricular rhythm as a manifestation of chronic renocardiac syndrome: A case report.
Ann Noninvasive Electrocardiol
July 2024
Third Department of Cardiology, Hippokration General Hospital of Thessaloniki, Thessaloniki, Greece.
Article Synopsis
- * Diagnostic tests indicated that the patient had heart failure with reduced ejection fraction and chronic kidney disease.
- * Daily hemodialysis sessions led to the restoration of sinus rhythm, highlighting how the removal of uremic toxins may help in managing AIVR, which usually has a favorable prognosis.
Adequacy of Dialysis and Incidence of Atrial Fibrillation in Patients Undergoing Hemodialysis.
Circ Cardiovasc Qual Outcomes
August 2024
Department of Internal Medicine, Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, Republic of Korea (G.Y.H., J.T.P., S.H.H., T.-H.Y., S.-W.K., H.W.K.).
Background: Atrial fibrillation (AF) can lead to stroke, heart failure, and mortality and has a greater prevalence in dialysis patients than in the general population. Several studies have suggested that uremic toxins may contribute to the development of AF. However, the association between dialysis adequacy and incident AF has not been well established.
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