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Real-world effects of antidepressants for depressive disorder in primary care: population-based cohort study.
Br J Psychiatry
December 2024
Oxford Precision Psychiatry Lab, National Institute for Health and Care Research (NIHR) Oxford Health Biomedical Research Centre, Oxford, UK.
Background: Antidepressants' effects are established in randomised controlled trials (RCTs), but not in the real world.
Aims: To investigate real-world comparative effects of antidepressants for depression and compare them with RCTs.
Method: We performed a cohort study based on the QResearch database.
Short-Term Risk of Type 2 Diabetes in Patients Using Various Antidepressants Compared with Patients Using Fluoxetine.
Psychiatry Clin Psychopharmacol
November 2024
Department of Psychiatry, Keimyung University School of Medicine, Daegu, Korea.
Background: The objective is to compare the risk of developing type 2 diabetes (T2D) within a year in patients prescribed various antidepressants (ADs) and those prescribed fluoxetine as a control group.
Methods: This study used standardized data from the Health Insurance Review and Assessment Service claims database (n=1,456,489). Patients aged ≥10 years with no previous use of ADs and no history of diabetes mellitus, regardless of whether they were diagnosed with any depressive disorder, were eligible for this study.
Drug-Induced Type 1 Brugada Pattern: A Case Report.
Cureus
November 2024
Internal Medicine, University Hospitals Sussex NHS Foundation Trust, St Richard's Hospital, Chichester, GBR.
Article Synopsis
- Brugada syndrome is a genetic heart disorder characterized by abnormal heart rhythms, leading to fainting and potential sudden death, even in otherwise healthy individuals.
- A 33-year-old man was diagnosed with drug-induced type 1 Brugada pattern after experiencing syncopal episodes that mimicked seizures, with no history of heart issues or epilepsy.
- The antidepressant dosulepin was identified as the likely trigger for the condition, and a psychiatry consult was recommended to evaluate medication alternatives.
Extended-spectrum beta-lactamase-producing Enterobacterales in human health: Experience from the tricycle project, Ghana.
PLoS One
November 2024
Department of Medical Microbiology, University of Ghana Medical School, College of Health Sciences, University of Ghana, Accra, Ghana.
Background: Vulnerable groups, such as pregnant women, are at increased risk of potentially life-threatening infections with extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-E) for both mother and newborn. However, data regarding ESBL-E carriage and associated risk factors in Ghanaian pregnant women remain scarce.
Objective: This study aimed to determine the prevalence of ESBL-E carriage and its associated risk factors among pregnant women attending the antenatal clinic at the Korle Bu Teaching Hospital.
Background Context: Recent work indicates no increased mortality risk with concurrent gabapentin and opioid use when using an active comparator control design. However, concurrent gabapentin and opioid prescriptions have been associated with greater risk of respiratory depression in some studies.
Purpose: To compare the risk of respiratory events among Medicare enrollees with spine-related diagnoses treated with gabapentin + opioids vs those treated with tricyclic antidepressants (TCA) or duloxetine + opioids.
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