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Distinguishing activated T regulatory cell and T conventional cells by single-cell technologies.
Immunology
May 2022
Center for Regenerative Therapies Dresden, Faculty of Medicine, TU Dresden, Dresden, Germany.
Resting conventional T cells (Tconv) can be distinguished from T regulatory cells (Treg) by the canonical markers FOXP3, CD25 and CD127. However, the expression of these proteins alters after T-cell activation leading to overlap between Tconv and Treg. The objective of this study was to distinguish resting and antigen-responsive T effector (Tconv) and Treg using single-cell technologies.
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