Mitosis hit with an ATM transaction fee: aurora B-mediated activation of ATM during mitosis.

Mol Cell

Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA 02111, USA.

Published: November 2011

In this issue of Molecular Cell, Yang et al. (2011) demonstrate that Aurora B phosphorylates ATM, leading to its mitotic activation and ability to phosphorylate Bub1 and regulate the spindle checkpoint, thus maintaining genomic integrity.

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http://dx.doi.org/10.1016/j.molcel.2011.11.001DOI Listing

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