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Double-Dynamic-Bond Cross-Linked Hydrogel Adhesive with Cohesion-Adhesion Enhancement for Emergency Tissue Closure and Infected Wound Healing.
Adv Healthc Mater
January 2025
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China.
The hydrogel adhesives with strong tissue adhesion and biological characteristics adhm202404447are urgently needed for injury sealing and tissue repair. However, the negative correlation between tissue adhesion and the mechanical strength poses a challenge for their practical application. Herein, a bio-inspired cohesive enhancement strategy is developed to prepare the hydrogel adhesive with simultaneously enhanced mechanical strength and tissue adhesion.
View Article and Find Full Text PDFBibliometric Insights Into Thromboelastography Research Using PubMed and VOSviewer.
Cureus
December 2024
Department of Anesthesiology, Tata Main Hospital, Jamshedpur, IND.
Thromboelastography (TEG) has evolved from a primarily surgical tool to a key instrument in broader medical fields, including personalized medicine for coagulopathies. The rationale for conducting this bibliometric analysis of TEG is to understand the evolution and current state of research in this critical field. By identifying publication trends, key contributors, and major developments, this study aims to provide valuable insights to guide future research and clinical practices in TEG.
View Article and Find Full Text PDFOut-of-Hospital Cardiac Arrest in Ireland 2012 to 2020: Bystander CPR, bystander defibrillation and survival in the Utstein comparator group.
Resusc Plus
January 2025
Foundation Professor of General Practice, Discipline of General Practice, University of Galway, Galway, Ireland.
Background: The Irish Out-of-Hospital Cardiac Arrest registry (OHCAR) collects data based on the internationally recognised Utstein template. The Utstein comparator group (bystander witnessed and initial shockable rhythm) has specific relevance in benchmarking out-of-hospital cardiac arrest (OHCA) health system performance.
Aims: To describe OHCA in the Utstein comparator group during 2012 to 2020 in Ireland.
Case report: A rare case of three synchronous colon tumors with metastasis to the left inguinal lymph node.
Front Oncol
January 2025
Department of Surgical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania.
This study presents a rare case of three synchronous colon tumors with metastasis to the left inguinal lymph node, challenging the conventional understanding of the metastatic pathways and highlighting the exceptional nature of such occurrences. This highlights the importance of considering alternative atypical metastatic routes for the management of colon cancer. A literature search was performed to identify similar cases.
View Article and Find Full Text PDFSuper-enhancers in tumors: unraveling recent advances in their role in Oncogenesis and the emergence of targeted therapies.
J Transl Med
January 2025
Department of Obstetrics and Gynecology, Department of Gynecologic Oncology Research Office, Guangzhou Key Laboratory of Targeted Therapy for Gynecologic Oncology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Super enhancers are a unique class of enhancers that possess a distinct structure and mechanism, which enable them to exhibit stronger gene transcription regulatory function than classical enhancers, thereby regulating cellular activities. In tumor samples, super enhancers have been identified as crucial players in the development and progression of tumor cells, opening up new avenues for cancer research and treatment. This review provides a concise overview of various models regarding super enhancer assembly and activation, examining the mechanisms through which tumor cells acquire or activate these enhancers and regulate carcinogenic transcription programs.
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