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Mild-to-moderate psoriasis is associated with subclinical inflammation in the duodenum and a tendency of disturbed intestinal barrier.
Biochim Biophys Acta Mol Basis Dis
December 2024
Department of Pharmacy, Uppsala University, Box 580, SE-751 23 Uppsala, Sweden; Gastroenterology Research Group, Department of Medical Sciences, Uppsala University Hospital, SE-751 85 Uppsala, Sweden. Electronic address:
Psoriasis is a chronic skin disease occasionally associated with abdominal symptoms and IBD. We aimed to characterize intestinal immune cells and the integrity of the intestinal barrier in psoriasis. Biopsies from the duodenum and colon were analyzed by flow cytometry and immunohistochemistry for the presence and activation status of different immune cell populations.
View Article and Find Full Text PDFSerum IL-23 levels reflect a myeloid inflammatory signature and predict the response to apremilast in patients with psoriatic arthritis.
Front Immunol
December 2024
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
Background: The phosphodiesterase 4 (PDE4) inhibitor apremilast downregulates the production of IL-23 and other pro-inflammatory cytokines involved in the pathogenesis of psoriatic arthritis (PsA).
Aim: To investigate the effects of apremilast on the production of cytokines by peripheral blood monocyte-derived macrophages, innate-like lymphocyte cells (ILCs), mucosal-associated invariant T (MAIT) cells, γδ T cells, natural killer (NK) cells, and NKT-like cells from patients with PsA manifesting different clinical responses to the treatment.
Methods: Peripheral blood samples were obtained from patients with PsA at baseline and after 1 and 4 months of apremilast therapy (n = 23) and 20 controls with osteoarthritis.
A Single-Center Cross-Sectional Observational Study on Dermoscopy of Genital Mucosal Disorders in a Tertiary Care Center in Central India.
Indian Dermatol Online J
October 2024
Department of Dermatology and Venereology, AIIMS, Habibganj, Saketnagar, Bhopal, Madhya Pradesh India.
Introduction: Dermoscopy of mucosa is known as mucoscopy. Mucoscopy can aid in delineating minute aspects of mucosal lesions and will guide in the differentiation of similar-looking lesions. To date, there are only a few studies on mucoscopy of genital dermatoses especially from India.
View Article and Find Full Text PDFThe Role of Vitamin D3 Deficiency and Colonization of the Oral Mucosa by Yeast-like Fungi in the Pathomechanism of Psoriasis.
J Clin Med
November 2024
Department of Aesthetic Dermatology, Faculty of Health Sciences, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland.
Psoriasis is a chronic inflammatory skin disease with complex pathogenesis and variable severity. Performed studies have indicated the impact of vitamin D3 deficiency on the pathogenesis of psoriasis and its severity. However, there is no clear evidence of the influence of the mucosal microbiome on the onset and progression of psoriasis.
View Article and Find Full Text PDFCesarean Delivery in a Patient With Hypermobile Ehlers-Danlos Syndrome: A Case Report.
Cureus
October 2024
Anesthesiology, Unidade Local de Saúde de Braga, Braga, PRT.
Article Synopsis
- - Patients with hypermobile Ehlers-Danlos syndrome (hEDS) experience symptoms like joint hypermobility, skin issues, and potential complications affecting the spine and respiratory system, requiring careful management during anesthesia.
- - A 24-year-old woman with hEDS underwent a cesarean delivery, with considerations for her medical history and previous anesthesia experiences influencing the anesthesia plan.
- - The anesthesia team utilized general anesthesia with videolaryngoscopy for intubation, ensuring safe patient positioning to avoid injuries and successfully managing the birth without complications.
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