[The influence of lipoic acid on total protein concentration in the liver and spleen tissue in rats during lipopolysaccharide-induced oxidative stress].

The Aim Of The Study: To evaluate the influence of lipoic acid on total protein concentration in the liver and spleen in rats during endotoxemia.

Material And Methods: Experiments were performed on Wistar rats divided into following groups: Group I (control) received saline; Group II (LA) received lipoic acid (60 mg/kg b.w.); Group III (LPS) received lipopolysaccharide (30 mg/kg b.w.); Group IV (LPS+LA) received LPS (30 mg/kg b.w.) and 30 min later LA (60 mg/kg b.w.). Five hours after last injection rats were sacrificed, and the liver and spleen were harvested for subsequent total protein assay.

Results: Lipoic acid administration led to a significant increase in total protein concentration in the liver and spleen tissue of endotoxemic rats when compared to control.

Conclusion: Lipoic acid administration during early phase of LPS-induced oxidative stress increase protein level in the liver and spleen tissue, which indicate an increase of antioxidant properties of an organism.