AI Article Synopsis
- The study analyzed 63 untransfused β-thalassemia intermedia patients to explore the link between fetal hemoglobin (HbF) levels and various health complications.
- HbF levels were found to positively correlate with total hemoglobin but negatively with certain markers of iron levels and ineffective erythropoiesis.
- A significant finding was that lower HbF levels were associated with a higher number of morbidities, with a specific HbF threshold indicating a strong predictor for the absence of these health issues.
Article Abstract
To evaluate the association between fetal hemoglobin (HbF) levels and morbidity in β-thalassemia intermedia (TI), we analyzed data from 63 untransfused patients who had also never received HbF induction therapy. Patient records were reviewed for any history of 10 predefined morbidities. Laboratory measurements for markers of ineffective erythropoiesis were also obtained. The mean age of patients was 32.1 years, 47.6% were males, and the median HbF level was 37.2%. HbF levels correlated positively with total hemoglobin, yet negatively with growth differentiation factor-15 and non-transferrin-bound iron levels. Median HbF levels were significantly lower in patients with the majority of evaluated morbidities than in those without. There was a strong negative adjusted linear correlation between the HbF level and the total number of morbidities (R(2) = 0.825, P < .001). The HbF threshold of 63.7% had 95.5% sensitivity and 100% specificity for ensuring absence of morbidity. There exists a strong association between HbF levels and morbidity in the subset of untransfused patients with TI.
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| http://dx.doi.org/10.1182/blood-2011-09-382408 | DOI Listing |
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