Male mice were subjected to repeated inhalation exposures to different concentrations (165, 204, 250, or 300 ppm) of ethylene oxide (EtO) during an 8.5-week period. Transmitted clastogenic effects of these exposures were measured in terms of induction of dominant lethal mutations and heritable translocations. The concentration-response curves for both endpoints are not linear but are markedly concave upward. Significant increases in dominant lethals were detected at all concentrations, except the lowest one. In comparison, the incidences of heritable translocations were significantly increased at all concentrations.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/em.2850160209 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
GWAS Identifies SNP Markers and Candidate Genes for Off-Flavours and Protein Content in Faba Bean ( L.).
Plants (Basel)
January 2025
Plant Breeding, Wageningen University & Research, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands.
Faba bean ( L.) is a valuable ingredient in plant-based foods such as meat and dairy analogues. However, its typical taste and aroma are considered off-flavours in these food applications, representing a bottleneck during processing.
View Article and Find Full Text PDFComparative Analysis of the Effects of Maternal Hypoxia and Placental Ischemia on HIF1-Dependent Metabolism and the Glucocorticoid System in the Embryonic and Newborn Rat Brain.
Int J Mol Sci
December 2024
Laboratory of Regulation of Brain Neuronal Functions, Pavlov Institute of Physiology, Russian Academy of Sciences, Makarova emb. 6, 199034 Saint-Petersburg, Russia.
Prenatal hypoxia, often accompanied by maternal glucocorticoid stress, can predispose offspring to neurological disorders in adulthood. If placental ischemia (PI) primarily reduces fetal oxygen supply, the maternal hypoxia (MH) model also elicits a pronounced fetal glucocorticoid exposure. Here, we compared MH and PI in rats to distinguish their unique and overlapping effects on embryonic and newborn brain development.
View Article and Find Full Text PDFEpigenetic modifications and emerging therapeutic targets in cardiovascular aging and diseases.
Pharmacol Res
January 2025
GMU-GIBH Joint School of Life Sciences, Department of Cardiology, Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, the Second Affiliated Hospital, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, State Key Laboratory of Respiratory Disease, The Sixth School of Clinical Medicine, the Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Guangzhou, Guangdong, PR China. Electronic address:
The complex mechanisms underlying the development of cardiovascular diseases remain not fully elucidated. Epigenetics, which modulates gene expression without DNA sequence changes, is shedding light on these mechanisms and their heritable effects. This review focus on epigenetic regulation in cardiovascular aging and diseases, detailing specific epigenetic enzymes such as DNA methyltransferases (DNMTs), histone acetyltransferases (HATs), and histone deacetylases (HDACs), which serve as writers or erasers that modify the epigenetic landscape.
View Article and Find Full Text PDFGenome-wide association insights into the genomic regions controlling vegetative and oil production traits in Acrocomia aculeata.
BMC Plant Biol
November 2024
Department of Genetics, "Luiz de Queiroz" College of Agriculture, São Paulo University, (ESALQ/USP), Piracicaba, Brazil.
Article Synopsis
- Macauba (Acrocomia aculeata) is a promising non-domesticated palm species with potential for oil production, comparable to the commercially used oil palm, driving interest in its genetic study for domestication efforts.
- The study utilized various genotyping strategies to identify SNPs in 201 palms and performed GWAS to associate genetic traits with vegetative and oil production characteristics, despite lacking a reference genome.
- Results indicated significant genetic variation among traits, with heritability values suggesting the presence of favorable genotypes for breeding programs; a total of 92 significant SNPs were identified in single-trait GWAS using de novo data.
Genetic polymorphism involved in major depressive disorder: a systemic review and meta-analysis.
BMC Psychiatry
October 2024
Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Background And Objective: Genetic polymorphism studies in families and twins indicated the heritability of depression. However, the association between genes with genetic polymorphism and depression provides various findings and remains unclear. Therefore, we conducted a systematic review and meta-analysis to determine the genes with their polymorphism associated with the symptomatic depression known as major depressive disorder (MDD).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!