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Rationale: With the recent introduction of the dynamically harmonized Fourier-transform ion cyclotron resonance (FT-ICR) cell, the complexity of tuning has expanded drastically, and fine-tuning of the direct current voltages is required to optimize the ion cloud movement. As this adjustment must typically be performed manually, more reliable computational methods would be useful.

Methods: Here we propose a computational method based on a design of experiments (DoE) strategy to overcome the limits of classical manual tuning.

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Methods: Analyses of a complex organic material simulating extraterrestrial matter (Titan's tholins) are performed with a homemade space-designed Orbitrap™ equipped with a laser ablation ionization source at 266 nm: the LAb-CosmOrbitrap.

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The aerosols present in the atmosphere of the Saturn's moon Titan are of particular planetary science interest and several spacecraft missions are already allowed to gather spectroscopic data. Titan haze's analogs, so-called tholins, were produced on earth to push forward the comprehension of their formation and properties. In this study, this highly complex mixture was analyzed here for the first time by trapped ion mobility spectrometry coupled to ultra-high resolution mass spectrometry (FTICR MS).

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Yokohama National University, 79-1 Tokiwadai, Hodogaya-ku, Yokohama, 240-8501, Japan. Electronic address:

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Low-Temperature Alkaline pH Hydrolysis of Oxygen-Free Titan Tholins: Carbonates' Impact.

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1 Laboratoire Interuniversitaire des Systèmes Atmosphériques (LISA), UMR CNRS 7583, Université Paris Est Créteil et Université Paris Diderot, Institut Pierre Simon Laplace, C.M.C., Créteil, France .

Titan, the largest moon of Saturn, is one of the key planetary objects in the field of exobiology. Its dense, nitrogen-rich atmosphere is the site of important organic chemistry. This paper focuses on the organic aerosols produced in Titan's atmosphere that play an important role in atmospheric and surface processes and in organic chemistry as it applies to exobiological interests.

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