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Anti-tumor Necrosis Factor Drug Concentration Is Not Associated with Disease Outcomes in Pouchitis: A Retrospective, International Study.
Dig Dis Sci
January 2025
INFINY Institute, Department of Gastroenterology, CHRU Nancy, INSERM NGERE, Université de Lorraine, 54500 , Vandœuvre-lès-Nancy, France.
Background: Therapeutic drug monitoring is important for optimizing anti-tumor necrosis factor-α (TNF-α) therapy in inflammatory bowel disease. However, the exposure-response relationship has never been assessed in pouchitis.
Aims: To explore associations between anti-TNF-α drug concentration and pouchitis disease activity in patients with a background of ulcerative colitis.
The Association Between Disordered Eating and Musculoskeletal Injury Among Marine Officers Upon Entry to the Basic School.
Mil Med
January 2025
Consortium for Health and Military Performance, Department of Military and Emergency Medicine, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA.
Introduction: Active duty service members (ADSMs) may be at heightened risk for eating disorders (EDs) and sub-clinical disordered eating (DE). ADSMs are also at a high risk for musculoskeletal injury (MSK-I). Given the risk for EDs/DE among ADSMs as well as robust physical requirements of military training, additional research is needed to elucidate links between DE and risk for MSK-I among ADSMs.
View Article and Find Full Text PDFDeciphering the biosynthetic pathway of triterpene saponins in Prunella vulgaris.
Plant J
January 2025
College of Horticulture, Bioinformatics Center, Academy for Advanced Interdisciplinary Studies, Nanjing Agricultural University, Nanjing, 210095, China.
The traditional Chinese medicinal plant Prunella vulgaris contains numerous triterpene saponin metabolites, notably ursolic and oleanolic acid saponins, which have significant pharmacological values. Despite their importance, the genes responsible for synthesizing these triterpene saponins in P. vulgaris remain unidentified.
View Article and Find Full Text PDFThe COVID-19 Impact on Employment for LGBT Individuals With Disabilities: An Examination of the 2021 Household Pulse Survey.
J Disabil Policy Stud
March 2025
University of New Hampshire, Durham, USA.
The 2021 Household Pulse Survey (HPS) was examined as it relates to coronavirus disease 2019 (COVID-19) and the impact on employment for the lesbian, gay, bisexual, and transgender (LGBT) community and members with disabilities. The purpose of the study was to understand the effect of COVID-19 on both groups as it relates to employment, specifically focusing on work loss. In analyzing the HPS, the population of the LGBT community was estimated as 7.
View Article and Find Full Text PDFArrhythmogenic Right Ventricular Cardiomyopathy in Monozygotic Twins-A Case Report.
J Clin Ultrasound
January 2025
Department of Gastroenterology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is the classic phenotype of arrhythmogenic cardiomyopathy. ARVC in twins have been reported rarely. Herein, we report an unusual case of young monozygotic twins with early disease onset presenting different course of disease progression and clinical manifestations.
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