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Geriatric medicine and Olympic elite sports-parallels and philosophies.
Age Ageing
October 2024
AGE Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Article Synopsis
- The 30th Olympiad in July 2024 highlights the surprising connections between elite sports and geriatric medicine.
- Both elite athletes and older individuals function at the edges of their physical limits, benefiting from specialized training and support from diverse teams.
- Lessons from sports science, especially regarding muscle function, can inform clinical interventions for age-related muscle loss (sarcopenia) and promote the importance of exercise for healthy aging.
Clinical effectiveness and safety of olaparib in BRCA-mutated, HER2-negative metastatic breast cancer in a real-world setting: final analysis of LUCY.
Breast Cancer Res Treat
April 2024
Department of Medical Oncology, BC Cancer, University of British Columbia, Vancouver, Canada.
Purpose: The interim analysis of the phase IIIb LUCY trial demonstrated the clinical effectiveness of olaparib in patients with germline BRCA-mutated (gBRCAm), human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (mBC), with median progression-free survival (PFS) of 8.11 months, which was similar to that in the olaparib arm of the phase III OlympiAD trial (7.03 months).
View Article and Find Full Text PDFMedical Care Management Based on Disaster Medicine for the Triathlon Events at the XXXII Olympiad and Tokyo 2020 Paralympic Games.
Int J Environ Res Public Health
October 2023
Department of Emergency, Disaster and Critical Care Medicine, School of Medicine, Showa University, Tokyo 142-8666, Japan.
Planning the medical services for the triathlon competition at the 2020 Tokyo Olympic and Paralympic Games was predicted to be challenging because of possible last-minute changes related to the COVID-19 pandemic and abnormally high temperatures. Therefore, event planners organized and executed a disaster medical care plan, a plan for providing care during emergencies. Based on the basic medical plan for all venues provided by the Tokyo 2020 Organizing Committee, planners for the triathlon venue prepared a medical care plan according to the CSCATTT principles: Command and control, Safety, Communication, Assessment, Treatment, Triage, and Transport.
View Article and Find Full Text PDFOlaparib efficacy in patients with germline BRCA-mutated, HER2-negative metastatic breast cancer: Subgroup analyses from the phase III OlympiAD trial.
Int J Cancer
August 2023
Beth Israel Deaconess Medical Center, Dana-Farber Harvard Cancer Center, Boston, Massachusetts, USA.
In the primary analysis of the phase III OlympiAD trial, olaparib significantly prolonged progression-free survival (PFS) vs chemotherapy treatment of physician's choice (TPC) in patients with germline BRCA-mutated (gBRCAm), HER2-negative metastatic breast cancer (mBC). We report subgroup analyses for the final analysis at a median OS follow-up of 18.9 months (olaparib) and 15.
View Article and Find Full Text PDFOlympiAD extended follow-up for overall survival and safety: Olaparib versus chemotherapy treatment of physician's choice in patients with a germline BRCA mutation and HER2-negative metastatic breast cancer.
Eur J Cancer
May 2023
Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy; Division of Medical Oncology 2, University of Padova and Istituto Oncologico Veneto IRCCS, Padova, Italy.
Background: In the Phase III OlympiAD study, olaparib significantly prolonged progression-free survival versus chemotherapy treatment of physician's choice (TPC) in patients with germline BRCA-mutated (gBRCAm), human epidermal growth factor receptor 2-negative metastatic breast cancer (mBC). In the final pre-specified analysis (64% maturity), median overall survival (OS) was 19.3 months for olaparib and 17.
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