AI Article Synopsis

  • The study evaluates the public health and economic effects of pediatric immunization programs using different pneumococcal conjugate vaccines (PCVs) in Germany, Greece, and the Netherlands.
  • A decision-analytic model was created to estimate the impact of three types of PCVs on invasive pneumococcal diseases (IPD), pneumonia (PNE), and acute otitis media (AOM), considering various epidemiological factors.
  • Results indicate that the 13-valent vaccine (PCV13) could significantly reduce IPD cases and is more cost-effective than the 7-valent (PCV7) and 10-valent (PCV10) vaccines when indirect effects are considered.

Article Abstract

Background: Seven-valent pneumococcal conjugate vaccine (PCV7) had profound public-health impacts and is considered cost-effective and potentially cost saving. Two new PCVs have been launched, a 10-valent vaccine (PCV10) and a 13-valent vaccine (PCV13). We examined public-health and economic impacts of PCV pediatric national immunization programs (NIPs) in Germany, Greece, and the Netherlands.

Methods: A decision-analytic model was developed to estimate the impact of PCV13, PCV7, and 10-valent pneumococcal conjugate vaccine (PCV10) on invasive pneumococcal disease (IPD), pneumonia (PNE), and acute otitis media (AOM). Using epidemiological data, we calculated the cases of IPD, PNE, and AOM, using country-specific incidence, serotype coverage, disease sequelae, mortality, vaccine effectiveness, indirect effects, costs, and utilities. Direct effects for PCV13- and PCV10-covered serotypes were assumed similar to PCV7. PCV13 was assumed to confer an indirect effect, while PCV10 was not. Assumptions were tested in sensitivity analyses.

Results: In a NIP, PCV13 was estimated to eliminate 31.7%, 46.4%, and 33.8% of IPD in Germany, Greece, and the Netherlands, respectively. Compared with PCV7 and PCV10, PCV13 was found to be cost-effective or cost saving in all cases when PCV13 indirect effects were included.

Conclusions: Pediatric NIPs with PCV13 in Europe are expected to have dramatic public-health impacts and be cost-effective or cost saving.

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http://dx.doi.org/10.1016/j.jinf.2011.10.015DOI Listing

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