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The transcriptional and translational landscape of HCoV-OC43 infection.
PLoS Pathog
January 2025
Discovery Research Platform for Hidden Cell Biology, University of Edinburgh, Edinburgh, Scotland, UK.
The coronavirus HCoV-OC43 circulates continuously in the human population and is a frequent cause of the common cold. Here, we generated a high-resolution atlas of the transcriptional and translational landscape of OC43 during a time course following infection of human lung fibroblasts. Using ribosome profiling, we quantified the relative expression of the canonical open reading frames (ORFs) and identified previously unannotated ORFs.
View Article and Find Full Text PDFUltrasound, Doppler and other signs during drug-free transition from subclinical hypothyroidism to euthyroidism: a case report.
AME Case Rep
January 2025
Ushakov Thyroid Clinic, Moscow, Russia.
Background: It is known that subclinical hypothyroidism (SCH) often converts to euthyroidism. However, the mechanism of such changes is unclear and can only be speculated. This difficulty is likely due to limitations in diagnostic guidelines and their interpretation.
View Article and Find Full Text PDFEffect of cold atmospheric plasma on common oral pathogenic microorganisms: a narrative review.
Ann Med
December 2025
Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun, People's Republic of China.
Background: The oral microbiota is a diverse and complex community that maintains a delicate balance. When this balance is disturbed, it can lead to acute and chronic infectious diseases such as dental caries and periodontitis, significantly affecting people's quality of life. Developing a new antimicrobial strategy to deal with the increasing microbial variability and resistance is important.
View Article and Find Full Text PDFExploring the Underlying Mechanism of Weiling Decoction Alleviates Cold-Dampness Diarrhea Based on Network Pharmacology, Transcriptomics, Molecular Docking and Experimental Validation.
Pharmaceuticals (Basel)
January 2025
National Key Laboratory of Veterinary Public Health Security, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
: Cold-dampness diarrhea (CDD) is a common gastrointestinal disorder in children, characterized by diarrhea and intestinal barrier dysfunction. Weiling decoction (WLD) is frequently used in clinical practice to treat CDD, a condition triggered by multiple factors. However, the molecular mechanisms underlying its therapeutic effects remain poorly understood.
View Article and Find Full Text PDFEffects of and Alkylamides on Respiratory Virus Replication and IL-8 Expression In Vitro.
Molecules
January 2025
Ric Scalzo Institute for Botanical Research, Sonoran University of Health Sciences, Tempe, AZ 85282, USA.
is a perennial medicinal herb with important immunomodulatory and anti-inflammatory properties, especially purported for the alleviation of cold and flu symptoms. Different classes of secondary metabolites of the plant, such as alkylamides, caffeic acid derivatives, polysaccharides, flavonoids, and glycoproteins, are believed to be biologically and pharmacologically active. Although previous research suggests that the alkylamides present in may be responsible for reducing the symptoms associated with the common cold or flu through their immunomodulatory activity, the roles of specific alkylamides and their targets (i.
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