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A Decade of Prevalence and Clinicopathological Insights Into Classical Hodgkin Lymphoma: A Study From an Indonesian Tertiary Hospital.
Cureus
November 2024
Anatomical Pathology Department, Faculty of Medicine, Dr. Cipto Mangunkusumo/Universitas Indonesia, Jakarta, IDN.
Article Synopsis
- Classical Hodgkin lymphoma (cHL) primarily affects young adults, and this study analyzed 739 cases at Dr. Cipto Mangunkusumo Hospital in Jakarta over a decade, focusing on patient demographics, tumor locations, and immunohistochemical (IHC) patterns.
- The most affected age group was 20-29 years, with a predominance of males; most tumors were found in nodal areas, particularly the mediastinum.
- The nodular sclerosis subtype was the most common and was significantly associated with early-stage diagnoses, indicating trends consistent with other Asian countries regarding age, gender, and disease stage.
Chemotherapy alone versus chemotherapy plus radiotherapy for adults with early-stage Hodgkin's lymphoma.
Cochrane Database Syst Rev
December 2024
Cochrane Haematology, Institute of Public Health, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Background: Early-stage Hodgkin's lymphoma in adults is commonly treated with combined modality treatment of chemotherapy followed by radiotherapy. The role of radiotherapy has been questioned due to potential long-term adverse effects.
Objectives: To assess the effects of chemotherapy compared to chemotherapy plus radiotherapy in adults with early-stage Hodgkin's lymphoma.
[Improved prognosis with radiotherapy in early-stage Hodgkin lymphoma: a critical analysis of the long-term data from the EORTC/LYSA/FIL H10 trial].
Strahlenther Onkol
November 2024
Klinik für Strahlentherapie - Radioonkologie, Universitätsklinikum Münster (UKM), Albert-Schweitzer-Campus 1, Gebäude A1, 48149, Münster, Deutschland.
Fifteen-Year Experience of a Single Institution: Outcomes for Early-Stage Hodgkins Lymphoma Comparing Chemotherapy Alone Versus Combined Modality Therapy.
Adv Radiat Oncol
December 2024
Department of Radiation Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia.
Purpose: Doxorubicin, bleomycin, vinblastine, dacarbazine (ABVD) chemotherapy is the current standard treatment for early-stage Hodgkins lymphoma (HL). The use of consolidative radiation therapy (RT) in addition to chemotherapy may lead to better survival rates but is controversial because of concerns about long-term toxicity. The aim of this study is to compare outcomes of patients receiving ABVD chemotherapy alone (CTX alone) versus ABVD with consolidative RT (CMT).
View Article and Find Full Text PDFExploring the complexity, treatment challenges, and outcomes in pediatric nodular lymphocyte predominant Hodgkin lymphoma: a perspective from a low-middle-income country.
Front Oncol
October 2024
Pediatric Oncology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
Background: In children, nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is an uncommon subtype of Hodgkin lymphoma. Given the lack of data on the best chemotherapy regimen, there is a knowledge gap in best management.
Methods: This retrospective study included all pediatric patients with NLPHL diagnosed and treated at the Children's Cancer Hospital, Egypt (2007-2018).
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