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Salivary gland organoid transplantation as a therapeutic option for radiation-induced xerostomia.
Stem Cell Res Ther
August 2024
R&D Institute, ORGANOIDSCIENCES Co., Ltd, 331, Pangyo-ro, Seongnam-si, 13488, Gyeonggi-do, Republic of Korea.
Background: Xerostomia is a pathological condition characterized by decreased salivation due to salivary gland dysfunction and is frequently attributed to irreversible damage as a side effect of radiation therapy. Stem cell-derived organoid therapy has garnered attention as a promising avenue for resolving this issue. However, Matrigel, a hydrogel commonly used in organoid culture, is considered inappropriate for clinical use due to its undefined composition and immunogenicity.
View Article and Find Full Text PDFPurine-Rich Element Binding Protein Alpha, a Nuclear Matrix Protein, Has a Role in Prostate Cancer Progression.
Int J Mol Sci
June 2024
Dr. Kiran C Patel College of Allopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.
Article Synopsis
- Solid tumors, leukemias, and lymphomas exhibit significant changes in nuclear structure, which are important for cancer diagnosis and may impact how cancer cells function.
- The nuclear matrix (NM) is essential for the nucleus's structure and interacts with various protein complexes that influence gene activity and DNA organization, potentially contributing to cancer progression.
- Research on LNCaP and LN96 prostate cancer cell lines shows that purine-rich element binding protein alpha (PURα) is a key NM protein that differs between the two cell lines, suggesting it may play a significant role in prostate cancer.
[Clinicopathological characteristics of angioimmunoblastic T-cell lymphoma with B-cell proliferation or neoplasms].
Zhonghua Bing Li Xue Za Zhi
July 2024
Department of Pathology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
Article Synopsis
- - The study examines angioimmunoblastic T-cell lymphoma (AITL) cases with a focus on their clinical, pathological, and immunophenotypic characteristics, as well as the differential diagnosis involving B-cell proliferation or neoplasms.
- - Eight cases from a hospital in China were analyzed, revealing one case of AITL with diffuse large B-cell lymphoma (DLBCL) and seven cases of AITL with B-cell proliferation, with an average patient age of 58 years.
- - The findings highlight distinct histological features and tumor behavior in AITL with B-cell involvement, suggesting that a combination of clinical, morphological, and molecular analyses is essential for accurate diagnosis.
Nucleolin acute degradation reveals novel functions in cell cycle progression and division in TNBC.
bioRxiv
June 2024
Department of Cancer Biology and Genetics, College of Medicine, The Ohio State University, 43210, Columbus, OH, USA.
Nucleoli are large nuclear sub-compartments where vital processes, such as ribosome assembly, take place. Technical obstacles still limit our understanding of the biological functions of nucleolar proteins in cell homeostasis and cancer pathogenesis. Since most nucleolar proteins are essential, their abrogation cannot be achieved through conventional approaches.
View Article and Find Full Text PDFNucleolar organization and ribosomal DNA stability in response to DNA damage.
Curr Opin Cell Biol
August 2024
Nucleolar Stress and Disease Group, Danish Cancer Institute, Strandboulevarden 49, 2100 Copenhagen, Denmark. Electronic address:
Eukaryotic nuclei are structured into sub-compartments orchestrating various cellular functions. The nucleolus is the largest nuclear organelle: a biomolecular condensate with an architecture composed of immiscible fluids facilitating ribosome biogenesis. The nucleolus forms upon the transcription of the repetitive ribosomal RNA genes (rDNA) that cluster in this compartment.
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