The authors submit available information on the restricted use of new antimicrobial chemotherapeutic agents--quinolones--in the treatment of bacterial endocarditis in experiments and under clinical conditions. Quinolones are not suitable for the treatment of endocarditis except when the aetiological agent is Ps. aeruginosa, enterobacteria and in some instances endocarditis caused by meticillin-resistant staphylococci. The mentioned aetiological agents, however, cause endocarditis only in cca 5-10%. The results of experimental investigations on animal models as well as case-histories from human medicine are promising in this respect.
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