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http://dx.doi.org/10.1016/j.eimc.2011.06.011 | DOI Listing |
Exp Parasitol
December 2024
Department of Biology, Graduate Education Institute, Mardin Artuklu University, Mardin, Türkiye.
A light and electron microscopic study of skin biopsies taken from 9 patients with ulcerative leishmaniasis of both sexes aged from 14 to 26 years in the territory of the Republic of Azerbaijan was carried out. Based on clinical, morphological and electron microscopic parameters, all patients were diagnosed with ulcerative cutaneous anthroponotic leishmaniasis (Leishmania (L.) tropica).
View Article and Find Full Text PDFSci Rep
December 2024
Department of Statistics, College of Natural and Computational Sciences, Gambella University, Gambella, Ethiopia.
Visceral leishmaniasis (VL) is a neglected tropical disease that mostly affects the working-class and impoverished segments of society, having a significant negative effect on the economic development of the affected nation. While anti-leishmanial medications lower mortality among VL patients, patients may still die or require more time to recover (TTR) while receiving treatment. In this regard, there are limited studies in Ethiopia.
View Article and Find Full Text PDFPLoS Negl Trop Dis
December 2024
Hospital Clínic Veterinari, Universitat Autònoma de Barcelona, Bellaterra, Spain.
The current standard treatment for canine leishmaniosis (CanL), N-methylglucamine antimoniate (MGA) given with allopurinol, is not fully effective and may cause adverse effects and drug resistance. In vitro and in vivo studies have shown that nucleotides, administered alone or with AHCC, offer benefits in the treatment of CanL. This study examines the effects of a new immunomodulatory treatment protocol in which dietary nucleotides and AHCC are added to the recommended standard treatment.
View Article and Find Full Text PDFParasit Vectors
December 2024
Koret School of Veterinary Medicine, The Hebrew University, Rehovot, Israel.
Background: In Europe, canine leishmaniasis is commonly caused by Leishmania infantum. Allopurinol is the main drug for long-term management of the disease, and clinical relapses of L. infantum infection treated with this drug are described.
View Article and Find Full Text PDFIndian J Dermatol
October 2024
From the Department of Pharmacology, Lovely Professional University, Phagwara, Punjab, India.
Post-kala-azar dermal leishmaniasis (PKDL) is a neglected skin disease that has tremendous epidemiological significance as a reservoir of Leishmania parasites. Relapse, drug resistance, non-compliance to prolonged treatment, poor health-seeking behaviour, along with limited therapeutic options pose a significant impact on the management of PKDL. In this study, we aimed to review the efficacy, safety and tolerability data of combination therapies for PKDL in the published literature.
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