Susceptibility to autoimmune myocarditis has been associated with histamine release by mast cells during the innate immune response to coxsackievirus B3 (CVB3) infection. To investigate the contribution of histamine H(1) receptor (H(1)R) signaling to CVB3-induced myocarditis, we assessed susceptibility to the disease in C57BL/6J (B6) H(1)R(-/-) mice. No difference was observed in mortality between CVB3-infected B6 and H(1)R(-/-) mice. However, analysis of their hearts revealed a significant increase in myocarditis in H(1)R(-/-) mice that is not attributed to increased virus replication. Enhanced myocarditis susceptibility correlated with a significant expansion in pathogenic Th1 and Vγ4(+) γδ T cells in the periphery of these animals. Furthermore, an increase in regulatory T cells was observed, yet these cells were incapable of controlling myocarditis in H(1)R(-/-) mice. These data establish a critical role for histamine and H(1)R signaling in regulating T cell responses and susceptibility to CVB3-induced myocarditis in B6 mice.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244571 | PMC |
| http://dx.doi.org/10.1016/j.cellimm.2011.10.004 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Pharmacological inhibition of histamine N-methyltransferase extends wakefulness and suppresses cataplexy in a mouse model of narcolepsy.
Sleep
October 2024
Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
Histamine, a neurotransmitter, plays a predominant role in maintaining wakefulness. Further, our previous studies showed that histamine N-methyltransferase (HNMT), a histamine-metabolising enzyme, is important for regulating brain histamine concentration. However, the effects of pharmacological HNMT inhibition on mouse behaviour, including the sleep-wake cycle and cataplexy, in a mouse model of narcolepsy have not yet been investigated.
View Article and Find Full Text PDFThe role of heterodimers formed by histamine H3 receptors and dopamine D1 receptors on the methamphetamine-induced conditioned place preference.
Eur J Pharmacol
October 2024
Department of Physiology and Pharmacology, School of Basic Medical Sciences, Health Science Center, Ningbo University, 818 Fenghua Road, Ningbo, Zhejiang, 315211, PR China, Ningbo. Electronic address:
Article Synopsis
- The study investigates how the interaction between histamine H3 receptors (H3R) and dopamine D1 receptors (D1R) impacts the rewarding effects of Methamphetamine (METH).
- Mice experiments showed that blocking H3R with a specific antagonist (Thioperamide) reduced METH's rewarding effects, while an H1R antagonist (Pyrilamine) did not have similar results.
- The findings suggest that targeting the H3R-D1R complex could be a potential strategy for treating METH use disorder.
Histamine H4 receptor and TRPV1 mediate itch induced by cadaverine, a metabolite of the microbiome.
Mol Pain
August 2024
Institute of Pain Medicine and Special Environmental Medicine, Nantong University, Nantong, China.
Cadaverine is an endogenous metabolite produced by the gut microbiome with various activity in physiological and pathological conditions. However, whether cadaverine regulates pain or itch remains unclear. In this study, we first found that cadaverine may bind to histamine 4 receptor (H4R) with higher docking energy score using molecular docking simulations, suggesting cadaverine may act as an endogenous ligand for H4R.
View Article and Find Full Text PDFTRPV1 and mast cell involvement in repeated variate stress-induced urinary bladder dysfunction in adult female mice.
Am J Physiol Renal Physiol
September 2024
Department of Neurological SciencesThe Larner College of Medicine, University of VermontBurlingtonVermontUnited States.
The etiology of interstitial cystitis/bladder pain syndrome (IC/BPS) is unknown but likely multifactorial. IC/BPS symptoms can be exacerbated by psychological stress, but underlying mechanisms remain to be defined. Transient receptor potential vanilloid 1 (TRPV1) channels, expressed on nerve fibers, have been implicated in bladder dysfunction and colonic hypersensitivity with stress in rodents.
View Article and Find Full Text PDFHistamine H receptors in dentate gyrus-projecting cholinergic neurons of the medial septum suppress contextual fear retrieval in mice.
Nat Commun
July 2024
Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Zhejiang Chinese Medical University, Hangzhou, China.
Fear memory is essential for survival and adaptation, yet excessive fear memories can lead to emotional disabilities and mental disorders. Despite previous researches have indicated that histamine H receptor (HR) exerts critical and intricate effects on fear memory, the role of HR is still not clarified. Here, we show that deletion of HR gene in medial septum (MS) but not other cholinergic neurons selectively enhances contextual fear memory without affecting cued memory by differentially activating the dentate gyrus (DG) neurons in mice.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!