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Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
West China Hospital of Sichuan University, Chengdu, China.
Background: Idiopathic normal pressure hydrocephalus (iNPH) is highly prevalent among elderly individuals, and there is a strong correlation between telomere length and biological aging. However, there is limited evidence to elucidate the relationship between telomere length and iNPH. This study aimed to investigate the associations between telomere length and iNPH using the Mendelian randomization (MR) method.
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Alzheimers Dement
December 2024
Indiana University School of Medicine, Stark Neurosciences Research Institute, Department of Neurology, Indianapolis, IN, USA.
Background: Diagnosis of Alzheimer's disease (AD) via MRI is costly and can be limited by regional availability. With the recent advancements and discovery of amyloid in the retina, diagnosis of AD and the effect of AD pathology on the retina is becoming well characterized. However, the prevalence of vascular contributions to cognitive impairment and dementia (VCID) and its effects on the retina are less well known.
View Article and Find Full Text PDFBackground: Recently, a highly significant brain proteome divergent modules change between Alzheimer's disease (AD) and CRND8 APP transgenic mice has been found. The M42 module is the module in human AD most highly correlated with amyloid and tau pathologies and cognitive decline. Among all proteins in this module, the (SPARC-related modular calcium-binding protein 1) SMOC1 is emerging as a robust biomarker of amyloid deposition in CSF.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
Max Delbrück Center for Molecular Medicine, Berlin, Germany.
Background: The microtubule-associated protein tau is the most commonly misfolded protein in neurodegenerative disorders including Alzheimer's disease and other related tauopathies. These neurological illnesses are hypothesized to share a common mechanism of disease progression, where pathogenic aggregates or 'seeds' of the tau protein function as templates promoting misfolding of functional, soluble tau protein. Under this premise, therapeutic strategies that modulate the seeding cascade, have high potential to interfere with the disease process.
View Article and Find Full Text PDFBackground: Objective and sensitive measures of everyday function are needed for accurate clinical diagnosis and evaluation of outcomes in clinical trials for dementia. However, most objective everyday function measures are difficult to administer and have not been validated against biomarkers of Alzheimer's disease (AD) neuropathology. This study evaluated the neuroimaging correlates of a highly sensitive, ecologically valid, and easily implementable performance-based test of function called the Virtual Kitchen Challenge (VKC).
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