Enriching modern pharmacotherapy through synergy assessment for the combination of natural products and synthetic drugs.

5-O-methylglovanon (5-O-MG) is a bioactive compound first isolated and characterized from Glycosmis plants. In this issue, Zhou et al. evaluated the anti-staphylococcal effects of 5-O-MG against ampicillin-resistant isolates of Staphylococcus aureus and S. epidermidis. The authors showed that the combination of 5-O-MG and ampicillin significantly increased the susceptibility of Staphylococcus strains to the drugs by decreasing MICs with a comparable anti-staphylococcal effect to that of β-lactamase inhibitors, suggesting that herbal compounds such as 5-O-MG may be potential candidates for the inhibitor of β-lactamases. This study is another example of synergy assessment of natural products in drug development to likely enrich modern pharmacotherapy.