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The Brave New World of Early Treatment of Multiple Sclerosis: Using the Molecular Biomarkers CXCL13 and Neurofilament Light to Optimize Immunotherapy.
Biomedicines
August 2022
Department of Neurology, Geisel School of Medicine at Dartmouth and Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA.
Multiple sclerosis (MS) is a highly heterogeneous disease involving a combination of inflammation, demyelination, and CNS injury. It is the leading cause of non-traumatic neurological disability in younger people. There is no cure, but treatments in the form of immunomodulatory drugs (IMDs) are available.
View Article and Find Full Text PDFFighting spirit expressed by women with breast cancer in professional-and peer-led online support groups: effects on outcomes.
Madridge J Cancer Study Res
October 2017
Temple University, Philadelphia, PA, USA.
Objective: Does fighting spirit reduce depression in women with breast cancer (BC)?
Methods: Unlike previous studies using questionnaires, we assessed fighting spirit by analyzing interaction in BC support groups. Three online groups were studied: synchronous professionally led groups (Life Beyond Cancer), asynchronous professionallyled groups (Bosom Buddies) and asynchronous peer-led bulletin board groups (Peer Bulletin Boards). The samples were predominantly Caucasian, married, highly educated, and had early stage cancer.
The Brave New World of clinical cancer research: Adaptive biomarker-driven trials integrating clinical practice with clinical research.
Mol Oncol
May 2015
Division of Quantitative Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, 2006-2010, USA. Electronic address:
Clinical trials are the final links in the chains of knowledge and for determining the roles of therapeutic advances. Unfortunately, in an important sense they are the weakest links. This article describes two designs that are being explored today: platform trials and basket trials.
View Article and Find Full Text PDFHistory of carotid artery stenting.
J Cardiovasc Surg (Torino)
February 2013
Division of Cardiology, University Hospital, Rue Micheli-du-Crest 24, Geneva, Switzerland.
The history of carotid artery stenting (CAS) was made by brave men and women who believed in a less invasive treatment modality than carotid endarterectomy (CEA) to treat carotid stenosis despite the risk--which was obviously present also with surgery--to cause a stroke, the very event that the procedure aimed to prevent. The bulky equipment, the lack of knowledge about the appropriate antithrombotic regimen, and the impossibility at early stage to influence distal embolization added to the pressure on the investigators. At times, the confrontation with the surgical community has been hard.
View Article and Find Full Text PDF[Dr. Elizabeth Ross: heroine and victim of the World War I in Serbia].
Srp Arh Celok Lek
December 2012
At the beginning of 1915, several months after the World War I started, Serbia was in an extremely difficult situation.The country was war-ravaged, full of sick and wounded soldiers, there was a desperate shortage of doctors, nurses and other medical personnel, and the epidemic of typhus fever exploded and violently attacked the entire country. At that time, however, a number of both foreign allied medical missions and individual volunteers, from various countries, mostly from Great Britain, came to Serbia to help.
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