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Eradication of Helicobacter pylori by a potassium-competitive acid blocker alone?
Scand J Gastroenterol
December 2024
Department of clinical and molecular medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Aims: , the dominating cause of gastric cancer, most often infects children initiating inflammation in the antral part and spreads orally to the oxyntic mucosa. Traditionally, eradication of has been based upon a combination of antibiotics together with a proton pump inhibitor (PPI) to reduce gastric destruction of the antibiotics. Recently it has been shown that the more efficient inhibitors of acid secretion, the potassium-competitive acid blockers (PCABs) in combination with amoxicillin alone gave highly sufficient eradication.
View Article and Find Full Text PDFCharacterization of Helicobacter pylori immunoreactive proteins NusB, isoprenyl transferase, and hypothetical protein via immunoproteomics and molecular modeling approaches.
Int J Biol Macromol
December 2024
Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, Pakistan. Electronic address:
The microaerophilic Gram-negative bacterium H. pylori is associated with various gastric complications and affects nearly half of the global population. Current sero-diagnostic methods for H.
View Article and Find Full Text PDFEfficacy of Lactobacillus spp. Supplementation in Helicobacter pylori Eradication: A Systematic Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis.
Helicobacter
December 2024
Department of Biotechnology, Berhampur University, Berhampur, Odisha, India.
Background: Helicobacter pylori infection is a major global health concern and has been associated with a number of gastrointestinal disorders. Probiotics, especially Lactobacillus spp., have been suggested to have beneficial effect in managing H.
View Article and Find Full Text PDFCurrent study of pathogenetic mechanisms and therapeutics of chronic atrophic gastritis: a comprehensive review.
Front Cell Dev Biol
December 2024
Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs, School of Pharmacy, Guangdong Medical University, Dongguan, China.
Chronic atrophic gastritis (CAG) is a prevalent digestive system disease characterized by atrophy of the gastric mucosa and the disappearance of inherent gastric glands. According to the theory of Correa's cascade, CAG is an important pathological stage in the transformation from normal condition to gastric carcinoma. In recent years, the global incidence of CAG has been increasing due to pathogenic factors, including infection, bile reflux, and the consumption of processed meats.
View Article and Find Full Text PDFThe role of MAPK pathway in gastric cancer: unveiling molecular crosstalk and therapeutic prospects.
J Transl Med
December 2024
Department of General Surgery, The Lu'an Affiliated Hospital of Anhui Medical University, Lu'an People's Hospital, Lu'an, 237000, China.
Gastric cancer remains a significant health burden globally, especially prevalent in Asian and European regions. Despite a notable decline in incidence in the United States and Western Europe over recent decades, the disease's persistence underscores the urgency for advanced research in its pathogenesis and treatment strategies. Central to this pursuit is the exploration of the mitogen-activated protein kinase (MAPK) pathway, a pivotal cellular mechanism implicated in the complex processes of gastric cancer development, including cellular proliferation, invasion, migration, and metastasis.
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