AI Article Synopsis
- A novel sesquiterpene lactone called aspfalcolide was isolated from the leaves of Asparagus falcatus and characterized using various analytical techniques such as IR, NMR, and X-ray diffraction.
- Aspfalcolide crystallizes in an orthorhombic space group and forms infinite chains through an intermolecular hydrogen bond.
- The compound demonstrated significant anti-angiogenic activity, inhibiting the proliferation, migration, and tube formation of human umbilical vein endothelial cells (HUVECs) with an IC(50) of 1.82 μM.
Article Abstract
In this study the novel caryophyllene type sesquiterpene lactone (aspfalcolide) has been isolated from the leaves of Asparagus falcatus (Linn.) and characterized by IR, 1D NMR, 2D NMR, EI-MS, HR-ESI-MS and X-ray single crystal diffraction analysis. The aspfalcolide crystallizes in the orthorhombic space group P2(1)2(1)2(1) with a = 6.37360(10), b = 7.6890(2), c = 27.3281(6) Å, α = β = γ = 90(°) and Z = 4. One intermolecular O-H⋯O hydrogen bond enforces these natural molecules to form infinite chains through the crystal. Aspfalcolide was screened for its anti-angiogenic activity in human umbilical vein endothelial cells (HUVECs) and the result showed the remarkable inhibitory effect of aspfalcolide on the proliferation (IC(50) 1.82 μM), migration and tube formation of HUVECs.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ejmech.2011.10.037 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!