Ternary Cu(II) complexes [Cu(II)(saltrp)(B)] (1,2), (saltrp=salicylidene tryptophan, B=1,10 phenathroline (1) or 2,2' bipyridine (2)) were synthesized and characterized. Complex 2 was structurally characterized by single crystal X-ray crystallography. The molecular structure shows a distorted square pyramidal coordination geometry (CuN(3)O(2)) in which the ONO donor Schiff base is bonded to the Cu(II) in the basal plane. The N,N donor heterocyclic base displays an axial-equatorial binding mode. CT-DNA binding studies revealed that the complexes show good binding propensity (Intrinsic binding constant, K(b)=3.32×10(5) M(-1) for 1 and K(b)=3.10×10(5) M(-1) for 2). The catalytic role of these complexes in the oxidative and hydrolytic cleavage of DNA was studied in detail. Complex 1 binds and cleaves DNA more efficiently as compared to 2. From the kinetic experiments, rate constants for the hydrolysis of phosphodiester bond of DNA backbone were determined as 1.94 h(-1) and 1.05 h(-1) for 1 and 2 respectively. It amounts to (2.93-5.41)×10(7) fold rate enhancement compared to uncatalyzed double stranded DNA, which is impressive as compared to related Cu(II) Schiff base complexes.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jinorgbio.2011.08.022 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Computational insight into the formation of cation-π/cation-lone pair complexes between 3d-metal (II) ions and furan.
J Mol Model
January 2025
Department of Chemistry, Handique Girls' College, Guwahati , 781001, Assam, India.
Context: Cation-π and cation-lone pair interactions between 3d-metal (II) ions [Fe(II), Co(II), Ni(II) and Cu(II)] and furan are explored in the formation of 1:1 and 1:2 type complexes. Both cation-π (IE = -192.27 to -312.
View Article and Find Full Text PDFSelf-sensitized Cu(ii)-complex catalyzed solar driven CO reduction.
Chem Sci
January 2025
Department of Chemical Sciences, Indian Institute of Science Education and Research Mohanpur 741246 Kolkata India
Developing a self-sensitized catalyst from earth-abundant elements, capable of efficient light harvesting and electron transfer, is crucial for enhancing the efficacy of CO transformation, a critical step in environmental cleanup and advancing clean energy prospects. Traditional approaches relying on external photosensitizers, comprising 4d/5d metal complexes, involve intermolecular electron transfer, and attachment of photosensitizing arms to the catalyst necessitates intramolecular electron transfer, underscoring the need for a more integrated solution. We report a new Cu(ii) complex, K[CuNDPA] (1[K(18-crown-6)]), bearing a dipyrrin amide-based trianionic tetradentate ligand, NDPA (HL), which is capable of harnessing light energy, despite having a paramagnetic Cu(ii) centre, without any external photosensitizer and photocatalytically reducing CO to CO in acetonitrile : water (19 : 1 v/v) with a TON as high as 1132, a TOF of 566 h and a selectivity of 99%.
View Article and Find Full Text PDFSustainable synthesis of benzimidazole-based Schiff base using reusable CaAlO nanophosphors catalyst: Insights into metal(II) complexes and DNA interactions.
Nucleosides Nucleotides Nucleic Acids
January 2025
Department of PG Studies and Research in Environmental Science, Kuvempu University, Shankaraghatta, India.
This article presents a new and facile method for the synthesis of Schiff base compounds with a benzimidazole group using a low-cost and reusable calcium aluminate nanophosphorus catalyst (CaAlO). This approach avoids harmful solvents and reactants, supporting a more environmentally friendly synthesis process. The catalyst maintained its activity and heterogeneity over four cycles with minimal loss of efficiency.
View Article and Find Full Text PDFβ-Diketonate Coordination: Vibrational Properties, Electronic Structure, Molecular Topology, and Intramolecular Interactions. Beryllium(II), Copper(II), and Lead(II) as Study Cases.
J Phys Chem A
January 2025
Novosibirsk State University, Pirogov str. 1, Novosibirsk 630090, Russian Federation.
Nine metal complexes formed by three symmetric β-diketonates (, acetylacetonate (), 1,1,1,3,3,3-hexafluoro-acetylacetonate (), and 2,2,6,6-tetramethylheptane-3,5-dionate ()) and three metal ions (with three different coordination geometries, , Be - tetrahedral, Cu - square planar, and Pb - "swing" square pyramidal) were investigated. The study combines structural analyses, vibrational spectroscopic techniques, and quantum chemical calculations with the aim of bridging crystal structure, electronic structure, molecular topology, and far-infrared (FIR) spectroscopic characteristics. The effect of intramolecular interactions on the structural, electronic, and spectroscopic features is the center of this study.
View Article and Find Full Text PDFUnusual variability of isomers in copper(II) complexes with 1,8-bis(2-hydroxybenzyl)-cyclam.
Dalton Trans
January 2025
Czech Academy of Sciences, J. Heyrovsky Institute of Physical Chemistry, Dolejškova 2155/3, 182 23 Prague 8, Czech Republic.
Copper isotopes and their complexes are intensively studied due to their high potential for applications in radiodiagnosis and radiotherapy. Here, we study the Cu complex of 1,8-bis(2-hydroxybenzyl)-cyclam (HL), which forms an unexpected variety of isomers differing in the mutual orientation of the substituents on the cyclam nitrogen atoms, the protonation of the phenolate pendant, and the ligand denticity. The interconversion of the isomers is rather slow, which made the isolation, identification and investigation of some of the individual species possible.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!