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Evaluating practical approaches for including MYOC variants alongside common variants for genetics-based risk stratification for glaucoma: Including MYOC Variants for Glaucoma Risk Stratification.
Am J Ophthalmol
March 2025
Statistical Genetics Lab, QIMR Berghofer Medical Research Institute, Herston, Brisbane, Queensland, 4006, Australia. Electronic address:
Objective: Rare variants in the MYOC gene are associated with glaucoma risk, with p.Gln368Ter the most common pathogenic variant in Europeans. Genetics-based risk stratification may aid with early diagnosis for glaucoma but it is unclear how best to combine the p.
View Article and Find Full Text PDFEstablishment and validation of a nomogram for predicting esophagogastric variceal bleeding in patients with liver cirrhosis.
World J Gastroenterol
March 2025
Department of Gastroenterology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha 410008, Hunan Province, China.
Background: Patients with decompensated liver cirrhosis suffering from esophagogastric variceal bleeding (EGVB) face high mortality.
Aim: To investigate the risk factors for EGVB in patients with liver cirrhosis and establish a diagnostic nomogram.
Methods: Patients with liver cirrhosis who met the inclusion criteria were randomly divided into training and validation cohorts in a 6:4 ratio in this retrospective research.
Analytical Validation of the High Concentrated Thrombin Time-To-Reptilase Time Ratio: A Proposed Assay for Monitoring Unfractionated Heparin in Patients With Low Fibrinogen Levels.
Int J Lab Hematol
March 2025
Division of Hematology, Department of Medicine, Phramongkutklao Hospital, Bangkok, Thailand.
Introduction: This study aimed to evaluate the analytical performance of the high-concentrated thrombin time-to-reptilase time (hcTT/RT) ratio as a novel assay to neutralize fibrinogen effects and improve accuracy in unfractionated heparin (UFH) monitoring and to validate its use in clinical samples with low fibrinogen levels.
Methods: A total of 240 heparin-spiked plasma samples, prepared from 30 normal plasma samples with varying UFH concentrations, were analyzed. The hcTT/RT ratio's correlation with anti-FXa activity and its sensitivity and specificity were compared with the hcTT assay.
Brazilian Portuguese version of the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) Axis I: Cross-cultural adaptation, criterion validity, and reliability.
Braz J Phys Ther
March 2025
Department of Postgraduate Program in Rehabilitation Sciences, Universidade Nove de Julho (UNINOVE) São Paulo, SP, Brazil.
Background: The Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) is a biaxial instrument used worldwide for TMD assessment.
Objective: To translate, cross-culturally adapt, and assess the criterion validity and reliability of the Brazilian Portuguese version of the DC/TMD Axis I.
Methods: The translation and cross-cultural adaptation of Axis I into Brazilian Portuguese followed the recommendations of the International Network for Orofacial Pain and Related Disorders Methodology.
Can large language models assist with pediatric dosing accuracy?
Pediatr Res
March 2025
Department of Nursing Sciences, School of Health Professions, Faculty of Medical and health Sciences, Tel Aviv University, Tel Aviv, Israel.
Background And Objective: Medication errors in pediatric care remain a significant healthcare challenge despite technological advancements, necessitating innovative approaches. This study aims to evaluate Large Language Models' (LLMs) potential in reducing pediatric medication dosage calculation errors compared to experienced nurses.
Methods: This cross-sectional study (June-August 2024) involved 101 nurses from pediatric and neonatal departments and three LLMs (ChatGPT-4o, Claude-3.
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